Findings

What do systematic reviews say?

2 questions · 2 findings · 2 reviews · Emergency and Critical Care

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 50%Moderate 1 · 50%High 0 · 0%

Corticosteroids vs placebo or usual care

Hospital mortality · children and adults with sepsis

Corticosteroids probably leads to lower hospital mortality compared with placebo or usual care (moderate certainty).

1 finding from 1 review

Corticosteroids for treating sepsis in children and adults 2019 · Cochrane Headline outcomes only
RR 0.9 [0.82, 0.99]
26 studies · 8183 participants
Moderate

Corticosteroids vs control

Early all‐cause mortality (≤ 3 months) Reported at: day 14; day 28; day 60; and in hospital · adults with acute respiratory distress syndrome

Corticosteroids showed no clear difference in early all‐cause mortality (≤ 3 months) Reported at: day 14; day 28;… compared with control (low certainty).

1 finding from 1 review

Pharmacological agents for adults with acute respiratory distress syndrome 2019 · Cochrane Headline outcomes only
RR 0.77 [0.57, 1.05]
6 studies · 574 participants
Low