Findings

What do systematic reviews say?

25 questions · 29 findings · 15 reviews · Airways

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 8 · 27.6%Low 7 · 24.1%Moderate 12 · 41.4%High 2 · 6.9%

Pulmonary rehabilitation plus inspiratory muscle training vs pulmonary rehabilitation alone

Health‐related quality of life · patients with chronic obstructive pulmonary disease

2 findings from 1 review

Inspiratory muscle training, with or without concomitant pulmonary rehabilitation, for chronic obstructive pulmonary… 2023 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 908 participants
Low
Inspiratory muscle training, with or without concomitant pulmonary rehabilitation, for chronic obstructive pulmonary… 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 657 participants
Very low

Pulmonary rehabilitation vs usual care

Health‐related quality of life Change in total score of St George Respiratory Questionnaire · post‐exacerbation COPD

1 finding from 1 review

Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease 2016 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 1003 participants
High

Inspiratory muscle training vs control or sham

Health‐related quality of life · patients with chronic obstructive pulmonary disease

2 findings from 1 review

Inspiratory muscle training, with or without concomitant pulmonary rehabilitation, for chronic obstructive pulmonary… 2023 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 182 participants
Very low
Inspiratory muscle training, with or without concomitant pulmonary rehabilitation, for chronic obstructive pulmonary… 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 86 participants
Moderate

Integrated disease management interventions vs usual care

Health‐related quality of life · patients with chronic obstructive pulmonary disease

1 finding from 1 review

Integrated disease management interventions for patients with chronic obstructive pulmonary disease 2021 · Cochrane Headline outcomes only
no estimate extracted
18 studies · 4321 participants
Moderate

Self‐management interventions vs usual care

Health‐related quality of life (HRQoL) · patients with chronic obstructive pulmonary disease

1 finding from 1 review

Self‐management interventions including action plans for exacerbations versus usual care in patients with chronic… 2017 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 1582 participants
High

Intervention not reported

Health‐related Quality of Life: Dyspnoea domain of the CRQ · people with chronic obstructive pulmonary disease

1 finding from 1 review

Optimal intensity and type of leg exercise training for people with chronic obstructive pulmonary disease 2011 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 212 participants
Moderate

Intervention not reported

Health‐related quality of life ‐ all trials Higher scores indicate improved health‐related quality of life · patients with chronic obstructive pulmonary disease who do not qualify for home oxygen therapy

1 finding from 1 review

Oxygen for breathlessness in patients with chronic obstructive pulmonary disease who do not qualify for home oxygen… 2016 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 267 participants
Low

Non‐invasive ventilation during exercise training vs exercise training alone or exercise training with sham non‐invasive ventilation

Health‐related quality of life Change in total score of St George Respiratory Questionnaire · patients with chronic obstructive pulmonary disease

1 finding from 1 review

Non‐invasive ventilation during exercise training for people with chronic obstructive pulmonary disease 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 48 participants
Moderate

NMES and exercise vs exercise (with or without sham NMES)

Health‐related quality of life · COPD

1 finding from 1 review

Neuromuscular electrostimulation for adults with chronic obstructive pulmonary disease 2018 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 122 participants
Very low

NMES vs usual care with or without sham interventions

Health‐related quality of life · COPD

1 finding from 1 review

Neuromuscular electrostimulation for adults with chronic obstructive pulmonary disease 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 72 participants
Very low

Smart technology vs face‐to‐face/digital and/or written support

Health‐related quality of life (HRQoL) · COPD

1 finding from 1 review

Computer and mobile technology interventions for self‐management in chronic obstructive pulmonary disease 2017 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 472 participants
Low

Summary of Findings Table ‐ Chronic non‐invasive ventilation vs standard treatment following a severe exacerbation

Change in the health‐related quality of life · post‐exacerbation COPD

2 findings from 1 review

Chronic non‐invasive ventilation for chronic obstructive pulmonary disease 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 219 participants
Very low
Chronic non‐invasive ventilation for chronic obstructive pulmonary disease 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 164 participants
Very low

Summary of Findings Table ‐ Chronic non‐invasive ventilation vs usual care

Change in the health‐related quality of life · stable COPD

2 findings from 1 review

Chronic non‐invasive ventilation for chronic obstructive pulmonary disease 2021 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 259 participants
Very low
Chronic non‐invasive ventilation for chronic obstructive pulmonary disease 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 200 participants
Very low

Yoga vs no breathing exercises

QoL · patients with chronic obstructive pulmonary disease

1 finding from 1 review

Breathing exercises for chronic obstructive pulmonary disease 2012 · Cochrane Headline outcomes only
no estimate extracted
1 study · 45 participants
Moderate

Diaphragmatic breathing vs no breathing exercises

Health‐related quality of life Change in total score of St George Respiratory Questionnaire · patients with chronic obstructive pulmonary disease

1 finding from 1 review

Breathing exercises for chronic obstructive pulmonary disease 2012 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Moderate

Mepolizumab 100 mg vs placebo

Change in SGRQ total score · patients with chronic obstructive pulmonary disease

1 finding from 1 review

Anti‐IL‐5 therapies for chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 1285 participants
Moderate

Mepolizumab 300 mg vs placebo

QoL · patients with chronic obstructive pulmonary disease

1 finding from 1 review

Anti‐IL‐5 therapies for chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 451 participants
Moderate

Mepolizumab 100 mg vs placebo

QoL · patients with chronic obstructive pulmonary disease

1 finding from 1 review

Anti‐IL‐5 therapies for chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 911 participants
Moderate

Mucolytic vs placebo

SGRQ Total SGRQ (Total) Score. Scale from: 0 to 100. Lower score indicates better quality of life. · chronic bronchitis or COPD

1 finding from 1 review

Mucolytic agents versus placebo for chronic bronchitis or chronic obstructive pulmonary disease 2019 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 2721 participants
Moderate

Pursed lip breathing vs no breathing exercises

Health‐related quality of life Dyspnoea domain of Hiratsuka scale Scores range from 0 to 100, with lower scores indicating less shortness of breath · patients with chronic obstructive pulmonary disease

1 finding from 1 review

Breathing exercises for chronic obstructive pulmonary disease 2012 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 60 participants
Low