Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews · HIV/AIDS

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 2 · 100%High 0 · 0%

HIV infection · High‐risk individuals (including serodiscordant couples, men who have sex with men and sex workers)

TDF probably leads to lower HIV infection compared with placebo (moderate certainty).

1 finding from 1 review

Antiretroviral pre‐exposure prophylaxis (PrEP) for preventing HIV in high‐risk individuals 2012 · Cochrane Headline outcomes only
RR 0.33 [0.2, 0.55]
2 studies · 4027 participants
Moderate

HIV infection · High‐risk HIV‐uninfected individuals (including serodiscordant couples, men who have sex with men and sex workers)

TDF+ FTC probably leads to lower HIV infection compared with placebo (moderate certainty).

1 finding from 1 review

Antiretroviral pre‐exposure prophylaxis (PrEP) for preventing HIV in high‐risk individuals 2012 · Cochrane Headline outcomes only
RR 0.49 [0.28, 0.85]
4 studies · 8813 participants
Moderate