Methotrexate vs alternative disease‐modifying antirheumatic drugs
Function · children and young people with JIA
1 finding from 1 review
- no estimate extracted1 study · 94 participantsLow
Findings
What do systematic reviews say?
8 questions · 8 findings · 5 reviews · Musculoskeletal
No studies found 2 · 25%GRADE not reported 0 · 0%Very low 1 · 12.5%Low 3 · 37.5%Moderate 1 · 12.5%High 1 · 12.5%
Methotrexate vs placebo
Function · children and young people with JIA
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Methotrexate vs placebo
Function · psoriatic arthritis
1 finding from 1 review
- no estimate extracted1 study · 221 participantsLow
Methotrexate vs other DMARDs
Function (leflunomide) · psoriatic arthritis
1 finding from 1 review
- no estimate extracted1 study · 31 participantsVery low
Oral methotrexate plus intra‐articular glucocorticoid vs intra‐articular glucocorticoid alone
Function · children and young people with JIA
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Rituximab (2 x 1000 mg) plus methotrexate vs methotrexate
Physical function · patients with rheumatoid arthritis
Rituximab (2 x 1000 mg) plus methotrexate leads to higher physical function (HAQ‐DI MCID = ‐0.22) Analysis 1.10 compared with methotrexate monotherapy (high certainty).
1 finding from 1 review
- RR 1.6 [1.2, 2.1]4 studies · 1161 participantsHigh
MTX treated vs no MTX treated
BASFI (score from 0 to 10, 0=excellent, 10=poor function) · Patients with AS
1 finding from 1 review
- no estimate extracted1 study · 35 participantsLow
Intervention not reported
Functional Status Health Assessment Questionnaire Disability Index . Scale from: 0 to 3 · patients with rheumatoid arthritis
1 finding from 1 review
- no estimate extracted2 studies · 298 participantsModerate