Findings

What do systematic reviews say?

10 questions · 10 findings · 6 reviews

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No studies found 4 · 40%GRADE not reported 0 · 0%Very low 1 · 10%Low 3 · 30%Moderate 1 · 10%High 1 · 10%

Methotrexate vs alternative disease‐modifying antirheumatic drugs

Function · children and young people with JIA

1 finding from 1 review

Methotrexate for juvenile idiopathic arthritis 2024 · Cochrane Headline outcomes only
no estimate extracted
1 study · 94 participants
Low

Methotrexate vs placebo

Function · children and young people with JIA

The review found no eligible studies for this question.

1 finding from 1 review

Methotrexate for juvenile idiopathic arthritis 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Methotrexate vs placebo

Function · psoriatic arthritis

1 finding from 1 review

Methotrexate for psoriatic arthritis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 221 participants
Low

Methotrexate vs other DMARDs

Function (leflunomide) · psoriatic arthritis

1 finding from 1 review

Methotrexate for psoriatic arthritis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 31 participants
Very low

Oral methotrexate plus intra‐articular glucocorticoid vs intra‐articular glucocorticoid alone

Function · children and young people with JIA

The review found no eligible studies for this question.

1 finding from 1 review

Methotrexate for juvenile idiopathic arthritis 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Rituximab (2 x 1000 mg) plus methotrexate vs methotrexate

Physical function · patients with rheumatoid arthritis

Rituximab (2 x 1000 mg) plus methotrexate leads to higher physical function (HAQ‐DI MCID = ‐0.22) Analysis 1.10 compared with methotrexate monotherapy (high certainty).

1 finding from 1 review

Rituximab for rheumatoid arthritis 2015 · Cochrane Headline outcomes only
RR 1.6 [1.2, 2.1]
4 studies · 1161 participants
High

Azathioprine vs methotrexate

Kidney function · adults with renal vasculitis for maintenance therapy

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for renal vasculitis in adults 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Leflunomide vs methotrexate

Kidney function · adults with renal vasculitis for maintenance therapy

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for renal vasculitis in adults 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

MTX treated vs no MTX treated

BASFI (score from 0 to 10, 0=excellent, 10=poor function) · Patients with AS

1 finding from 1 review

Methotrexate for ankylosing spondylitis 2013 · Cochrane Headline outcomes only
no estimate extracted
1 study · 35 participants
Low

Intervention not reported

Functional Status Health Assessment Questionnaire Disability Index . Scale from: 0 to 3 · patients with rheumatoid arthritis

1 finding from 1 review

Methotrexate for treating rheumatoid arthritis 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 298 participants
Moderate