What do systematic reviews say?

Antidepressants vs placebo

Antidepressants may leads to lower failure to respond compared with placebo (low certainty).

• Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
  RR 0.72 [0.66, 0.79]
  30 studies · 6500 participants
  Low

Antidepressants vs benzodiazepines

Antidepressants showed no clear difference in failure to respond compared with benzodiazepines (low certainty).

• Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
  RR 0.99 [0.67, 1.47]
  2 studies · 215 participants
  Low

Tricyclic antidepressants vs placebo

Tricyclic antidepressants probably leads to lower failure to respond compared with placebo (moderate certainty).

• Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
  RR 0.73 [0.63, 0.86]
  9 studies · 829 participants
  Moderate

Selective serotonin reuptake inhibitors vs placebo

Selective serotonin reuptake inhibitors may leads to lower failure to respond compared with placebo (low certainty).

• Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
  RR 0.75 [0.67, 0.84]
  21 studies · 4000 participants
  Low

Serotonin and noradrenaline reuptake inhibitors (SNRI) vs placebo

Serotonin‐norepinephrine reuptake inhibitors may leads to lower failure to respond compared with placebo (low certainty).

• Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
  RR 0.61 [0.41, 0.91]
  4 studies · 1531 participants
  Low

Selective serotonin reuptake inhibitors vs benzodiazepines

It is very uncertain whether SSRIs changes failure to respond compared with benzodiazepines (very low certainty).

• Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
  RR 0.93 [0.48, 1.8]
  1 study · 154 participants
  Very low

Tricyclic antidepressants vs SSRI

TCAs showed no clear difference in failure to respond compared with SSRI (low certainty).

• Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
  RR 1.08 [0.71, 1.66]
  4 studies · 438 participants
  Low

Tricyclic antidepressants vs MAOI

TCA showed no clear difference in failure to respond compared with MAOI (low certainty).

• Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
  RR 0.59 [0.28, 1.26]
  1 study · 135 participants
  Low

Selective serotonin reuptake inhibitors vs MAOI

SSRIs showed no clear difference in failure to respond compared with MAOIs (moderate certainty).

• Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
  RR 1.12 [0.83, 1.52]
  2 studies · 396 participants
  Moderate

Selective serotonin reuptake inhibitors vs SNRIs

SSRIs showed no clear difference in failure to respond compared with SNRIs (high certainty).

• Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
  RR 0.96 [0.75, 1.23]
  2 studies · 991 participants
  High

Selective serotonin reuptake inhibitors vs NaSSAs

• Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Tricyclic antidepressants vs benzodiazepines

It is very uncertain whether TCAs changes failure to respond compared with benzodiazepines (very low certainty).

• Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
  RR 1.02 [0.63, 1.67]
  1 study · 61 participants
  Very low