What do systematic reviews say?

LAMA add‐on vs ICS alone

LAMA add‐on leads to lower exacerbations requiring oral corticosteroids (OCS) compared with ICS alone (high certainty).

• Long‐acting muscarinic antagonists (LAMA) added to inhaled corticosteroids (ICS) versus the same dose of ICS alone for… 2015 · Cochrane Headline outcomes only
  OR 0.65 [0.46, 0.93]
  4 studies · 2277 participants
  High