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What do systematic reviews say?

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Evidence found and GRADE certainty

5 questions · 8 findings · 1 reviews

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No studies found 3 · 37.5%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 12.5%Moderate 3 · 37.5%High 1 · 12.5%

14 days on/off antibiotic regimen vs 28 days on/off antibiotic regimen

Exacerbation frequency · people with bronchiectasis

14 days on/off antibiotic regimen showed no clear difference in exacerbation frequency compared with 28 days on/off antibiotic regimen (moderate certainty).

2 findings from 1 review

14 days on/off antibiotic regimen vs 14 days on/off placebo regimen

Exacerbation frequency · people with bronchiectasis

14 days on/off antibiotic regimen probably leads to lower exacerbation frequency compared with 14 days on/off placebo regimen (moderate certainty).

2 findings from 1 review

28 days on/off antibiotic regimen vs 28 days on/off placebo regimen

Exacerbation frequency · people with bronchiectasis

28 days on/off antibiotic regimen showed no clear difference in exacerbation frequency compared with 28 days on/off placebo regimen (high certainty).

2 findings from 1 review