Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews · Orthodontics

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No studies found 0 · 0%GRADE not reported 2 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

ACP light-cure adhesive vs Conventional/control orthodontic adhesive (e.g., Transbond XT) or negative control

Enamel demineralization (DIAGNOdent score) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)

A single triple-blinded RCT found the ACP-containing adhesive reduced enamel demineralization versus a conventional adhesive over 6 months (ungraded).

1 finding from 1 review

Can Orthodontic Adhesive Systems Inhibit the Formation and Development of White Spot Lesions During Fixed Orthodontic… 2024 All outcomes
1 and 6 months · Orthodontic clinical practice (in-vivo human clinical trials); adolescents and adults
Alshammari 2019 (1 triple-blinded RCT, 26 patients / 255 teeth): DIAGNOdent demineralization scores were lower with ACP than control at 1 month (2.58 +/-1.11 vs 3.39 +/-1.29) and 6 months (3.41 +/-1.11 vs 4.32…
1 study · 26 participants
GRADE not reported

nCaF2 primer vs Control Transbond primer

White spot lesions assessed by laser fluorescence (DIAGNOdent) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)

A single small split-mouth RCT found the nCaF2-containing primer reduced demineralization (DIAGNOdent) but showed no significant clinical white spot lesion difference at debonding (ungraded).

1 finding from 1 review

Can Orthodontic Adhesive Systems Inhibit the Formation and Development of White Spot Lesions During Fixed Orthodontic… 2024 All outcomes
1, 3 and 6 months (during treatment to debonding) · Orthodontic clinical practice (in-vivo human clinical trials); adolescents and adults
Al Tuma 2023 (1 split-mouth RCT, 31 patients / 310 teeth): DIAGNOdent scores significantly favored the nCaF2 primer at 1, 3 and 6 months (p=0.000) and S. mutans count differed at 1 month; no significant difference in…
1 study · 31 participants
GRADE not reported