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Evidence found and GRADE certainty

1 questions · 1 findings · 1 reviews · Common Mental Disorders

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 1 · 100%High 0 · 0%

Lithium vs valproate

Efficacy: remission (categorical) YMRS ≤ 12 and no increase in MADRS at end of study · acute mania

Lithium showed no clear difference in efficacy: remission (categorical) YMRS ≤ 12 and no increase in MADRS… compared with valproate (moderate certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 0.78 [0.46, 1.32]
    1 study · 257 participants
    Moderate