Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews · Common Mental Disorders

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 33.3%Low 2 · 66.7%Moderate 0 · 0%High 0 · 0%

Memantine vs placebo

Efficacy: number of participants who respond to treatment ‐ at 3 months · adults (aged 18 years+) with depression in bipolar disorder

Memantine showed no clear difference in efficacy: number of participants who respond to treatment ‐ at 3… compared with placebo (low certainty).

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder 2021 · Cochrane Headline outcomes only
OR 1.66 [0.69, 4.03]
2 studies · 261 participants
Low

Cytidine vs placebo

Efficacy: number of participants who respond to treatment ‐ at 3 months · adults (aged 18 years+) with depression in bipolar disorder

It is very uncertain whether cytidine changes efficacy: number of participants who respond to treatment ‐ at 3… compared with placebo (very low certainty).

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder 2021 · Cochrane Headline outcomes only
OR 1.13 [0.3, 4.24]
1 study · 35 participants
Very low

N‐acetylcysteine vs placebo

Efficacy: number of participants who respond to treatment ‐ at 3 months · adults (aged 18 years+) with depression in bipolar disorder

N‐acetylcysteine showed no clear difference in efficacy: number of participants who respond to treatment ‐ at 3… compared with placebo (low certainty).

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder 2021 · Cochrane Headline outcomes only
OR 0.82 [0.32, 2.14]
2 studies · 69 participants
Low