Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Hepato-Biliary

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No studies found 1 · 14.3%GRADE not reported 0 · 0%Very low 6 · 85.7%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Colchicine vs no intervention

Early mortality (mortality up to 90 days) · participants with alcoholic hepatitis (all severity)

It is very uncertain whether colchicine changes early mortality (mortality up to 90 days) compared with no intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
OR 3.18 [0.13, 81.01]
1 study · 69 participants
Very low

Insulin plus glucagon vs no intervention

Early mortality (mortality up to 90 days) · participants with alcoholic hepatitis (all severity)

It is very uncertain whether insulin plus glucagon changes early mortality (mortality up to 90 days) compared with no intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
OR 2.57 [0.92, 7.15]
1 study · 72 participants
Very low

Glucocorticosteroids vs no intervention

Early mortality (mortality up to 90 days) · participants with alcoholic hepatitis (all severity)

It is very uncertain whether glucocorticosteroids changes early mortality (mortality up to 90 days) compared with no intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
OR 1 [0.71, 1.39]
4 studies · 672 participants
Very low

Propylthiouracil vs no intervention

Early mortality (mortality up to 90 days) · participants with alcoholic hepatitis (all severity)

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Glucocorticosteroids vs no intervention

Early mortality (mortality up to 90 days) · participants with severe alcoholic hepatitis

It is very uncertain whether glucocorticosteroids changes early mortality (mortality up to 90 days) compared with no intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
OR 1.01 [0.71, 1.43]
2 studies · 607 participants
Very low

Pentoxifylline vs no intervention

Early mortality (mortality up to 90 days) · participants with severe alcoholic hepatitis

It is very uncertain whether pentoxifylline changes early mortality (mortality up to 90 days) compared with no intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
OR 1.18 [0.81, 1.74]
1 study · 545 participants
Very low

Pentoxifylline vs no intervention

Early mortality (mortality up to 90 days) · participants with alcoholic hepatitis (all severity)

It is very uncertain whether pentoxifylline changes early mortality (mortality up to 90 days) compared with no intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
OR 1.18 [0.81, 1.74]
1 study · 545 participants
Very low