Early childhood caries (ECC) - association with genetically predicted expression of CDH17 (chr8q22.1) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted expression of CDH17 was significantly associated with ECC in the TWAS (p = 3.32e-8); genetic association, ungraded.
1 finding from 1 review
Early childhood caries (ECC) - association at lead SNP rs1044956 (7:24854765; nearest gene(s) OSBPL3, NPVF) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
The common variant rs1044956 near OSBPL3, NPVF showed suggestive (not genome-wide significant) association with ECC (Z = 4.551, p = 5.35e-6); genetic association, ungraded.
2 findings from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of IGSF5 (chr21q22.2) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted IGSF5 expression reached the TWAS threshold for ECC (p = 7.22e-5) but was flagged as a possible false positive (LD misspecification) and not further considered; ungraded.
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of LACC1 (chr13q14.11) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted LACC1 expression reached the TWAS threshold for ECC (p = 3.98e-5) but was flagged as a possible false positive (LD misspecification) and not further considered; ungraded.
1 finding from 1 review
Early childhood caries (ECC) - association at lead SNP rs74470773 (3:33958083; nearest gene(s) PDCD6IP) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
The common variant rs74470773 near PDCD6IP showed suggestive (not genome-wide significant) association with ECC (Z = -4.589, p = 4.46e-6); genetic association, ungraded.
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of TAS2R43 (chr12p13.2) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted expression of TAS2R43 was significantly associated with ECC in the TWAS (p = 8.78e-8); genetic association, ungraded.
1 finding from 1 review
Early childhood caries (ECC) - association at lead SNP rs76823412 (8:134690570; nearest gene(s) ST3GAL1) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
The common variant rs8091366 near CHST9, KCTD1 showed suggestive (not genome-wide significant) association with ECC (Z = 4.476, p = 7.60e-6); genetic association, ungraded.
2 findings from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of TAS2R31 (chr12p13.2) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted expression of TAS2R31 was suggestively associated with ECC in the TWAS (p = 1.04e-5); genetic association, ungraded.
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of TAS2R14 (chr12p13.2) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted expression of TAS2R14 was significantly associated with ECC in the TWAS (p = 1.06e-6); genetic association, ungraded.
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of SMIM10L1 (chr12p13.2) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted expression of SMIM10L1 was significantly associated with ECC in the TWAS (p = 1.70e-7); genetic association, ungraded.
1 finding from 1 review
Early childhood caries (ECC) - association at lead SNP rs563135 (10:115067899; nearest gene(s) TCF7L2, CASP7) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
The common variant rs563135 near TCF7L2, CASP7 showed suggestive (not genome-wide significant) association with ECC (Z = -4.532, p = 5.86e-6); genetic association, ungraded.
1 finding from 1 review
Early childhood caries (ECC) - association at lead SNP rs7325099 (13:28104496; nearest gene(s) LNX2, POLR1D, RPL21) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
The common variant rs7325099 near LNX2, POLR1D, RPL21 showed suggestive (not genome-wide significant) association with ECC (Z = 4.485, p = 7.28e-6); genetic association, ungraded.
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of NRAD1 (LINC00284) (chr13q14.11) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted NRAD1 (LINC00284) expression reached the TWAS threshold for ECC (p = 1.69e-6) but was flagged as a possible false positive (LD misspecification) and not further considered; ungraded.
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of LINC02905 (C8orf49) (chr8p23.1) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted LINC02905 (C8orf49) expression reached the TWAS threshold for ECC (p = 1.82e-8) but was flagged as a possible false positive (LD misspecification) and not further considered; ungraded.
1 finding from 1 review
Early childhood caries (ECC) · Children aged 0-5 years in North Africa
Paternal tertiary education was associated with lower odds of ECC (OR 0.381).
3 findings from 1 review
OR 0.381 [0.16, 0.91]
1 study
GRADE not reported
OR 0.083 [0.03, 0.21]
1 study
GRADE not reported
OR 0.797 [0.171, 0.650]
1 study
GRADE not reported
Early childhood caries (ECC) · Children aged 0-5 years in North Africa
Brushing twice daily was associated with lower odds of ECC (OR 0.033).
2 findings from 1 review
OR 0.033 [0.004, 0.276]
1 study
GRADE not reported
OR 0.033 [0.004, 0.263]
1 study
GRADE not reported
Early childhood caries (ECC) · Preschool children (<6 years)
Higher sugar consumption is associated with early childhood caries in children under 6 years: pooled OR 1.59 (95% CI 1.50 to 1.68) from 9 cohort studies with no heterogeneity (I2=0%); the body of evidence was not GRADE-rated (ungraded).
1 finding from 1 review
Early childhood caries (ECC) · Children aged 0-5 years in North Africa
Brushing at the recommended time was associated with lower odds of ECC (OR 0.028).
1 finding from 1 review
OR 0.028 [0.004, 0.223]
1 study
GRADE not reported
Early childhood caries (ECC) · Children aged 0-5 years in North Africa
Caries in the mother's mouth was associated with markedly higher odds of ECC (OR 20.44).
1 finding from 1 review
OR 20.44 [8.37, 49.92]
1 study
GRADE not reported
Early childhood caries (ECC) · Children aged 0-5 years in North Africa
Spoon sharing with household members was associated with higher odds of ECC (OR 8.79).
1 finding from 1 review
OR 8.79 [2.92, 26.51]
1 study
GRADE not reported