Findings

What do systematic reviews say?

2 questions · 2 findings · 2 reviews · Movement Disorders

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 1 · 50%High 1 · 50%

Dropouts due to adverse events · patients with restless legs syndrome

Summary of findings: levodopa showed no clear difference in dropouts due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Levodopa for the treatment of restless legs syndrome 2011 · Cochrane Headline outcomes only
OR 0.73 [0.05, 11.34]
6 studies · 109 participants
Moderate

Withdrawals due to adverse events · patients with restless legs syndrome according to IRLSSG, 18 years or older

Summary of findings: dopamine agonists leads to higher number of dropouts due to adverse events compared with placebo (high certainty).

1 finding from 1 review

Dopamine agonists for the treatment of restless legs syndrome 2011 · Cochrane Headline outcomes only
OR 1.82 [1.35, 2.45]
34 studies · 7054 participants
High