Findings

What do systematic reviews say?

201 questions · 212 findings · 77 reviews

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No studies found 49 · 23.1%GRADE not reported 23 · 10.8%Very low 66 · 31.1%Low 48 · 22.6%Moderate 25 · 11.8%High 1 · 0.5%

Psychological intervention with or without other rehabilitation vs control (usual care/other rehabilitation)

Depression · patients with coronary heart disease

1 finding from 1 review

Psychological interventions for coronary heart disease 2017 · Cochrane Headline outcomes only
no estimate extracted
19 studies · 5829 participants
Low

Benzodiazepines (systemic clonazepam) vs placebo

Change in QoL - depression (surrogate marker) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether benzodiazepines (systemic clonazepam) changes change in QoL - depression (surrogate marker) compared with placebo (very low certainty).

1 finding from 1 review

Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes
short-term (up to 3 months) · systemic clonazepam
MD -0.20 [-0.95, 0.55]
1 study · 20 participants
Very low

Dietary supplements (lycopene) vs placebo

Change in QoL - depression (surrogate marker) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether dietary supplements (lycopene) changes change in QoL - depression (surrogate marker) compared with placebo (very low certainty).

1 finding from 1 review

Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes
short-term (up to 3 months) · lycopene
MD -1.87 [-4.23, 0.49]
1 study · 50 participants
Very low

Physical barriers (tongue protector) vs placebo

Change in QoL - depression (surrogate marker) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether physical barriers (tongue protector) changes change in QoL - depression (surrogate marker) compared with placebo (very low certainty).

1 finding from 1 review

Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes
short-term (up to 3 months)
MD -0.64 [-3.98, 2.70]
1 study · 50 participants
Very low

Telephone support vs usual care

Psychological health: Depression End of intervention · Informal caregivers of adults with diagnosed illnesses

1 finding from 1 review

Telephone interventions, delivered by healthcare professionals, for providing education and psychosocial support for… 2019 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 792 participants
Very low

Telephone support vs non‐telephone support intervention

Psychological health: Depression End of intervention · Informal caregivers of adults with diagnosed illnesses

1 finding from 1 review

Telephone interventions, delivered by healthcare professionals, for providing education and psychosocial support for… 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 11 participants
Very low

Tricyclic antidepressants vs placebo

Depressive symptoms · somatoform disorders in adults

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

New‐generation antidepressants vs placebo

Endpoint score (HDRS or MADRS) · somatoform disorders in adults

1 finding from 1 review

Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 163 participants
Very low

Culturally and literacy adapted self‐management programme vs written information on the same topic

Health outcome – Any depression Time point a: short‐term (immediately post‐intervention) Multiple measures used: PHQ‐9K (score · migrants

1 finding from 1 review

Interventions for improving health literacy in migrants 2023 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 555 participants
Very low

Natural products vs placebo

Depression (post‐treatment score on self report and clinician‐rated scales) Different self report and clinician‐rated scales (HDRS, BDI) · somatoform disorders in adults

1 finding from 1 review

Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 321 participants
Low

Antidepressants vs a combination of medications

Depression (post‐treatment score on self report and clinician‐rated scales) Different self report and clinician‐rated scales (HDRS, BDI) · somatoform disorders in adults

1 finding from 1 review

Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 107 participants
Very low

Tricyclic antidepressants vs another medication

Depression (post‐treatment score on self report and clinician‐rated scales) Different self report and clinician‐rated scales (HDRS, BDI) · somatoform disorders in adults

1 finding from 1 review

Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 395 participants
Low

Intervention not reported

Any depression Multiple measures used. CES‐D (Blanchard 1996; Kozachik 2001; Kuijer 2004; Kurtz 2005; McCorkle 2007). POMS Depression subscale (Bultz 2000; Campbell 2007). HADS‐D (Nicolaisen 2018; Robertson 2016). Additional study (reported in com... · informal caregivers of people affected by cancer

1 finding from 1 review

Psychosocial interventions for informal caregivers of people living with cancer 2019 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 702 participants
Moderate

Intervention not reported

Any depression Multiple measures used. CES‐D (Blanchard 1996;McCorkle 2007). POMS Depression subscale (Bultz 2000). HADS‐D (Nicolaisen 2018; Robertson 2016). Higher scores indicate higher levels of depression. Folllow‐up: Three to six months post‐... · informal caregivers of people affected by cancer

1 finding from 1 review

Psychosocial interventions for informal caregivers of people living with cancer 2019 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 379 participants
Low

Laigle‐Donadey 2019: dexamfetamine sulfate vs placebo

Depressive symptoms · people with a primary brain tumour

1 finding from 1 review

Interventions for the management of fatigue in adults with a primary brain tumour 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 41 participants
Very low

Education, self‐monitoring plus education, and decision aids vs usual care

Depression Measured after 52 weeks HADS depression score, 0‐21 points Low score means fewer symptoms · oral anticoagulant therapy in patients with atrial fibrillation

1 finding from 1 review

Educational and behavioural interventions for anticoagulant therapy in patients with atrial fibrillation 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 587 participants
Low

Relaxation vs usual care

Major depression · people with ESKD

The review found no eligible studies for this question.

1 finding from 1 review

Psychosocial interventions for preventing and treating depression in dialysis patients 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Spiritual practice vs usual care

Major depression · people with ESKD

The review found no eligible studies for this question.

1 finding from 1 review

Psychosocial interventions for preventing and treating depression in dialysis patients 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Counselling vs usual care

Major depression · people with ESKD

The review found no eligible studies for this question.

1 finding from 1 review

Psychosocial interventions for preventing and treating depression in dialysis patients 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Integrated CBT vs Twelve Step Facilitation

Depression score · co‐occurring depression and substance use disorders

2 findings from 1 review

Psychological interventions for co‐occurring depression and substance use disorders 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 212 participants
Very low
Psychological interventions for co‐occurring depression and substance use disorders 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 181 participants
Very low