Findings

What do systematic reviews say?

3 questions · 3 findings · 3 reviews · Oral Health

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No studies found 0 · 0%GRADE not reported 3 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Multiple LTF gene variants (joint / gene-based) vs Caries-free controls

Dental caries · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

A gene-based analysis indicated that multiple LTF variants were jointly associated with dental caries risk (weighted TPM P = 0.0007; no pooled effect estimate; ungraded).

1 finding from 1 review

The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based analysis. 2020 All outcomes
Brazil; United States; European countries; China · Gene-based joint association (LTF)
P-value (gene-based, weighted TPM) 0.0007
Studies not reported
GRADE not reported

Vitamin D vs placebo or control

Dental caries · children

Meta-analysis of randomised trials of vitamin D supplementation for Dental caries: RR 0.53 (95% CI 0.43 to 0.65), statistically significant. Umbrella review outcome-level evidence grade: Probable.

1 finding from 1 review

Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational… 2014 All outcomes
RR 0.53 [0.43, 0.65]
38 studies · 1513 participants
GRADE not reported

Disability (developmental, intellectual, or sensory) vs Persons without disabilities

Dental caries prevalence and severity · Persons with disabilities (children and adults with autism, Down syndrome, cerebral palsy, hearing impairment, or multiple disabilities)…

Dental caries prevalence and severity are high among persons with disabilities in Saudi Arabia (60% to over 80%), and the one comparative autism study reported significantly higher caries than controls; synthesized narratively (ungraded).

1 finding from 1 review

Disabilities and Disparities in Oral Health-Related Quality of Life: A Systematic Review and Meta-Analysis in Saudi… 2024 All outcomes
Cross-sectional · Autism centres and dental/hospital settings in Saudi Arabia (Riyadh, Jeddah)
Narrative synthesis (no pooled estimate). High dental caries burden among PWDs: caries prevalence 60% to over 80% (abstract). Alkahtani 2019 (hearing-impaired adults, single-arm): caries prevalence 82.2%, treatment…
Studies not reported
GRADE not reported