Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

33 questions · 33 findings · 11 reviews · Headline outcomes only

No studies found 16 · 48.5%GRADE not reported 0 · 0%Very low 7 · 21.2%Low 5 · 15.2%Moderate 2 · 6.1%High 3 · 9.1%

Homocysteine‐lowering interventions (high dose) vs homocysteine‐lowering interventions (low dose)

Death by any cause · people with or without existing cardiovascular disease, men and women

Homocysteine‐lowering interventions (high dose) showed no clear difference in death by any cause compared with homocysteine‐lowering interventions (low dose) (moderate certainty).

1 finding from 1 review

Homocysteine‐lowering interventions (Folic Acid, Vitamin B6 and Vitamin B12) vs placebo or usual care

Death by any cause · people with or without existing cardiovascular disease, men and women

Homocysteine‐lowering interventions (Vitamin B6 (pyridoxine;… showed no clear difference in death by any cause compared with placebo or standard care (high certainty).

1 finding from 1 review