Findings

What do systematic reviews say?

9 questions · 9 findings · 3 reviews · Haematology

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 22.2%Moderate 4 · 44.4%High 3 · 33.3%

Fewer vs more courses of chemotherapy (with or without radiotherapy

Death · Patients with untreated Hodgkin lymphoma (early stages)

Fewer showed no clear difference in death compared with more courses of chemotherapy (with or without radiotherapy (high certainty).

1 finding from 1 review

Optimisation of chemotherapy and radiotherapy for untreated Hodgkin lymphoma patients with respect to second malignant… 2017 · Cochrane Headline outcomes only
HR 0.99 [0.73, 1.34]
3 studies · 2403 participants
High

Dose‐intensified chemotherapy vs ABVD‐like chemotherapy (with or without radiotherapy

Death · Patients with untreated Hodgkin lymphoma (advanced stages)

Dose‐intensified chemotherapy showed no clear difference in death compared with ABVD‐like chemotherapy (with or without radiotherapy (moderate certainty).

1 finding from 1 review

Optimisation of chemotherapy and radiotherapy for untreated Hodgkin lymphoma patients with respect to second malignant… 2017 · Cochrane Headline outcomes only
HR 0.85 [0.7, 1.04]
7 studies · 2996 participants
Moderate

Chemotherapy alone vs same chemotherapy plus radiotherapy

Death · Patients with untreated Hodgkin lymphoma (early and advanced stages)

Chemotherapy alone showed no clear difference in death compared with same chemotherapy plus radiotherapy (moderate certainty).

1 finding from 1 review

Optimisation of chemotherapy and radiotherapy for untreated Hodgkin lymphoma patients with respect to second malignant… 2017 · Cochrane Headline outcomes only
HR 0.71 [0.46, 1.11]
3 studies · 1011 participants
Moderate

Chemotherapy plus involved‐field radiation vs same chemotherapy plus extended‐field radiation

Death · Patients with untreated Hodgkin lymphoma (early stages)

Chemotherapy plus involved‐field radiation showed no clear difference in death compared with same chemotherapy plus extended‐field radiation (high certainty).

1 finding from 1 review

Optimisation of chemotherapy and radiotherapy for untreated Hodgkin lymphoma patients with respect to second malignant… 2017 · Cochrane Headline outcomes only
HR 0.89 [0.7, 1.12]
4 studies · 2397 participants
High

Chemotherapy plus lower‐dose radiation vs same chemotherapy plus higher‐dose radiation

Death · Patients with untreated Hodgkin lymphoma (early stages)

Chemotherapy plus lower‐dose radiation showed no clear difference in death compared with same chemotherapy plus higher‐dose radiation (high certainty).

1 finding from 1 review

Optimisation of chemotherapy and radiotherapy for untreated Hodgkin lymphoma patients with respect to second malignant… 2017 · Cochrane Headline outcomes only
HR 0.91 [0.65, 1.28]
3 studies · 2962 participants
High

Intervention not reported

Relapses/death (instead of PFS) · Participants with PCNSL

The intervention may leads to lower relapses/death (instead of PFS) (low certainty).

1 finding from 1 review

The role of additional radiotherapy for primary central nervous system lymphoma 2014 · Cochrane Headline outcomes only
HR 0.79 [0.63, 0.99]
1 study · 411 participants
Low

Intervention not reported

Relapse, progression or death (calculated instead of PFS)

The intervention probably leads to lower relapse, progression or death (calculated instead of PFS) (moderate certainty).

1 finding from 1 review

Chemotherapy alone versus chemotherapy plus radiotherapy for adults with early stage Hodgkin lymphoma 2017 · Cochrane Headline outcomes only
HR 0.42 [0.25, 0.72]
4 studies · 1351 participants
Moderate

Intervention not reported

Relapse, progression or death (calculated instead of PFS)

The intervention showed no clear difference in relapse, progression or death (calculated instead of PFS) (low certainty).

1 finding from 1 review

Chemotherapy alone versus chemotherapy plus radiotherapy for adults with early stage Hodgkin lymphoma 2017 · Cochrane Headline outcomes only
HR 0.42 [0.14, 1.24]
3 studies · 1176 participants
Low

Intervention not reported

Relapse, progression or death (calculated instead of PFS) sensitivity analysis ‐ without HD6trial due to high risk of other bias

The intervention probably leads to lower relapse, progression or death (calculated instead of PFS)… (moderate certainty).

1 finding from 1 review

Chemotherapy alone versus chemotherapy plus radiotherapy for adults with early stage Hodgkin lymphoma 2017 · Cochrane Headline outcomes only
HR 0.24 [0.07, 0.88]
900 participants
Moderate