Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

12 questions · 12 findings · 3 reviews · Heart

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 4 · 33.3%Low 3 · 25%Moderate 3 · 25%High 2 · 16.7%

Homocysteine‐lowering interventions (high dose) vs homocysteine‐lowering interventions (low dose)

Death by any cause · people with or without existing cardiovascular disease, men and women

Homocysteine‐lowering interventions (high dose) showed no clear difference in death by any cause compared with homocysteine‐lowering interventions (low dose) (moderate certainty).

1 finding from 1 review

Homocysteine‐lowering interventions (Folic Acid, Vitamin B6 and Vitamin B12) vs placebo or usual care

Death by any cause · people with or without existing cardiovascular disease, men and women

Homocysteine‐lowering interventions (Vitamin B6 (pyridoxine;… showed no clear difference in death by any cause compared with placebo or standard care (high certainty).

1 finding from 1 review

Psychological intervention with or without other rehabilitation vs control (usual care/other rehabilitation)

Total mortalityDeaths · patients with coronary heart disease

Psychological intervention with or without other rehabilitation showed no clear difference in total mortalityDeaths compared with control (usual care/other rehabilitation) (moderate certainty).

1 finding from 1 review

Psychological intervention with or without other rehabilitation vs control (usual care/other rehabilitation)

Cardiac mortalityDeaths · patients with coronary heart disease

Psychological intervention with or without other rehabilitation may leads to lower cardiac mortalityDeaths compared with control (usual care/other rehabilitation) (low certainty).

1 finding from 1 review