Findings

What do systematic reviews say?

6 questions · 6 findings · 3 reviews · Kidney and Transplant

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 16.7%Low 2 · 33.3%Moderate 2 · 33.3%High 1 · 16.7%

Death · adults with renal vasculitis for maintenance therapy

Azathioprine may leads to lower death compared with methotrexate (low certainty).

1 finding from 1 review

Interventions for renal vasculitis in adults 2020 · Cochrane Headline outcomes only
RR 0.33
1 study · 126 participants
Low

Death (all causes) · adults with renal vasculitis for maintenance therapy

Azathioprine showed no clear difference in death (median compared with cyclophosphamide (moderate certainty).

1 finding from 1 review

Interventions for renal vasculitis in adults 2020 · Cochrane Headline outcomes only
RR 0.77 [0.35, 1.72]
1 study · 144 participants
Moderate

Death · Patients with maintenance treatment in lupus nephritis

It is very uncertain whether azathioprine (AZA) changes death compared with mycophenolate mofetil (MMF) (very low certainty).

1 finding from 1 review

Immunosuppressive treatment for proliferative lupus nephritis 2018 · Cochrane Headline outcomes only
RR 1.15 [0.34, 3.87]
4 studies · 451 participants
Very low

Adverse event causing death or study drug discontinuation · adults with renal vasculitis for maintenance therapy

Azathioprine showed no clear difference in adverse events causing death or study drug discontinuation compared with methotrexate (low certainty).

1 finding from 1 review

Interventions for renal vasculitis in adults 2020 · Cochrane Headline outcomes only
RR 0.58 [0.25, 1.38]
1 study · 126 participants
Low

Death, all cause · patients with kidney transplant recipients

Mycophenolate mofetil (MMF) showed no clear difference in death, all cause compared with azathioprine (AZA) (moderate certainty).

1 finding from 1 review

Mycophenolic acid versus azathioprine as primary immunosuppression for kidney transplant recipients 2015 · Cochrane Headline outcomes only
RR 0.95 [0.7, 1.29]
16 studies · 2987 participants
Moderate

Graft loss censored for death · patients with kidney transplant recipients

Mycophenolate mofetil (MMF) leads to lower graft loss, censored for death compared with azathioprine (AZA) (high certainty).

1 finding from 1 review