Findings

What do systematic reviews say?

6 questions · 7 findings · 1 reviews · Common Mental Disorders

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 6 · 85.7%Low 1 · 14.3%Moderate 0 · 0%High 0 · 0%

Antidepressants vs placebo

Clinical response of depression · adults with psychotic depression

It is very uncertain whether antidepressant changes clinical response of depression compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
RR 8.4 [0.5, 142.27]
1 study · 27 participants
Very low

Antidepressants vs antipsychotics

Clinical response of depression · adults with psychotic depression

It is very uncertain whether antidepressant changes clinical response of depression compared with antipsychotic (very low certainty).

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
RR 2.09 [0.64, 6.82]
1 study · 36 participants
Very low

Antidepressant plus antipsychotic vs placebo

Clinical response of depression · adults with psychotic depression

It is very uncertain whether antidepressant plus antipsychotic changes clinical response of depression compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
RR 1.86 [1.23, 2.82]
2 studies · 148 participants
Very low

Antidepressant plus antipsychotic vs placebo/no adjunctive treatment + antipsychotics

Clinical response of depression · adults with psychotic depression

Antidepressant plus antipsychotic may leads to higher clinical response of depression compared with placebo plus antipsychotic (low certainty).

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
RR 1.83 [1.4, 2.38]
4 studies · 447 participants
Low

Antidepressant plus antipsychotic vs placebo plus antidepressant

Clinical response of depression · adults with psychotic depression

It is very uncertain whether antidepressant plus antipsychotic changes clinical response of depression compared with placebo plus antidepressant (very low certainty).

2 findings from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
RR 1.42 [1.11, 1.8]
4 studies · 245 participants
Very low
Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
RR 1.7 [1.19, 2.43]
3 studies · 157 participants
Very low

Antipsychotics vs placebo

Clinical response of depression · adults with psychotic depression

It is very uncertain whether antipsychotic changes clinical response of depression compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
RR 1.13 [0.74, 1.73]
2 studies · 201 participants
Very low