Findings

What do systematic reviews say?

65 questions · 66 findings · 16 reviews

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No studies found 24 · 36.4%GRADE not reported 0 · 0%Very low 15 · 22.7%Low 13 · 19.7%Moderate 6 · 9.1%High 8 · 12.1%

Antibiotics vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Failure to induce clinical remission at end of study · people with active UC

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotics for the induction and maintenance of remission in ulcerative colitis 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral 5‐aminosalicylic acid vs placebo

Failure to maintain clinical or endoscopic remission · Patients with quiescent ulcerative colitis

Oral 5‐aminosalicylic acid leads to lower failure to maintain clinical or endoscopic remission compared with placebo (high certainty).

1 finding from 1 review

Oral 5‐aminosalicylic acid for maintenance of remission in ulcerative colitis 2020 · Cochrane Headline outcomes only
RR 0.68 [0.61, 0.76]
8 studies · 1555 participants
High

Once daily dosing vs conventional dosing

Failure to maintain clinical or endoscopic remission · Patients with quiescent ulcerative colitis

Once‐daily dosing showed no clear difference in failure to maintain clinical or endoscopic remission compared with conventional dosing (high certainty).

1 finding from 1 review

Oral 5‐aminosalicylic acid for maintenance of remission in ulcerative colitis 2020 · Cochrane Headline outcomes only
RR 0.94 [0.88, 1.01]
10 studies · 3910 participants
High

Oral 5‐aminosalicylic acid vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Failure to maintain clinical or endoscopic remission · Patients with quiescent ulcerative colitis

Oral 5‐aminosalicylic acid showed no clear difference in failure to maintain clinical or endoscopic remission compared with comparator 5‐aminosalicylic acid formulation (low certainty).

1 finding from 1 review

Oral 5‐aminosalicylic acid for maintenance of remission in ulcerative colitis 2020 · Cochrane Headline outcomes only
RR 1.08 [0.91, 1.28]
6 studies · 707 participants
Low

Antibiotics vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Failure to maintain clinical remission at end of study · Patients with quiescent ulcerative colitis

It is very uncertain whether antibiotics changes failure to maintain clinical remission at end of study compared with 5‐ASA (very low certainty).

1 finding from 1 review

Antibiotics for the induction and maintenance of remission in ulcerative colitis 2022 · Cochrane Headline outcomes only
RR 0.71 [0.47, 1.06]
1 study · 40 participants
Very low