Findings

What do systematic reviews say?

7 questions · 7 findings · 3 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 5 · 71.4%Moderate 1 · 14.3%High 1 · 14.3%

Letrozole vs laparoscopic ovarian drilling

Clinical pregnancy rate · infertile women with polycystic ovary syndrome

Letrozole showed no clear difference in clinical pregnancy rate compared with laparoscopic ovarian drilling (low certainty).

1 finding from 1 review

Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome 2022 · Cochrane Headline outcomes only
OR 1.47 [0.95, 2.28]
3 studies · 376 participants
Low

Letrozole with or without adjuncts vs SERMs with or without adjuncts followed by timed intercourse

Clinical pregnancy rate · infertile women with polycystic ovary syndrome

Letrozole with or without adjuncts leads to higher clinical pregnancy rate compared with SERMs with or without adjuncts followed by timed intercourse (high certainty).

1 finding from 1 review

Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome 2022 · Cochrane Headline outcomes only
OR 1.69 [1.45, 1.98]
23 studies · 3321 participants
High

Clomiphene citrate or letrozole with or without gonadotropins (with or without midcycle antagonist) vs gonadotropins (with GnRH agonists or midcycle antagonist)

Clinical pregnancy rate · for controlled ovarian stimulation

Clomiphene citrate or letrozole with or without gonadotropins (with… showed no clear difference in clinical pregnancy rate per woman compared with gonadotropins (with GnRH agonists or midcycle antagonist) (moderate certainty).

1 finding from 1 review

Oral medications including clomiphene citrate or aromatase inhibitors with gonadotropins for controlled ovarian… 2017 · Cochrane Headline outcomes only
RR 1 [0.86, 1.16]
12 studies · 1998 participants
Moderate

Clomiphene citrate or letrozole with or without gonadotropins (with or without midcycle antagonist) vs gonadotropins (with GnRH agonists or midcycle antagonist)

Clinical pregnancy rate · Women undergoing controlled ovarian stimulation in IVF and ICSI cycles (poor responders)

1 finding from 1 review

Oral medications including clomiphene citrate or aromatase inhibitors with gonadotropins for controlled ovarian… 2017 · Cochrane Headline outcomes only
RR 0.85 [0.64, 1.12]
8 studies · 1462 participants
Low

Progesterone vs placebo/no treatment

Clinical pregnancy rate · women with gonadotropin plus oral (clomiphene citrate or letrozole) stimulation

Progesterone may leads to higher clinical pregnancy rate compared with placebo/no treatment (low certainty).

1 finding from 1 review

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
RR 1.4 [1.03, 1.9]
4 studies · 733 participants
Low

Progesterone vs placebo/no treatment

Miscarriage per clinical pregnancy · women with gonadotropin plus oral (clomiphene citrate or letrozole) stimulation

Progesterone showed no clear difference in miscarriage rate per clinical pregnancy compared with placebo/no treatment (low certainty).

1 finding from 1 review

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
RR 0.67 [0.3, 1.5]
2 studies · 123 participants
Low

Progesterone vs placebo/no treatment

Miscarriage per clinical pregnancy · women with oral (clomiphene citrate or letrozole) stimulation

Progesterone showed no clear difference in miscarriage rate per clinical pregnancy compared with placebo/no treatment (low certainty).

1 finding from 1 review

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
RR 0.53 [0.25, 1.14]
2 studies · 119 participants
Low