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Evidence found and GRADE certainty

2 questions · 3 findings · 1 reviews · Childhood Cancer

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 3 · 100%High 0 · 0%

Dexrazoxane vs no cardioprotective intervention or placebo

Heart failure · adults with cancer receiving anthracyclines

Dexrazoxane probably leads to lower clinical heart failure Available case analysis compared with no cardioprotective intervention or placebo (moderate certainty).

1 finding from 1 review

Dexrazoxane vs no cardioprotective intervention or placebo

Clinical heart failure and subclinical myocardial dysfunction combined Comparable definitions; see Characteristics of included studies for exact definitions. Available‐case analysis · adults with cancer receiving anthracyclines

Dexrazoxane probably leads to lower clinical heart failure and subclinical myocardial dysfunction… compared with no cardioprotective intervention or placebo (moderate certainty).

2 findings from 1 review