Findings

What do systematic reviews say?

99 questions · 102 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 68 · 66.7%Very low 18 · 17.6%Low 11 · 10.8%Moderate 5 · 4.9%High 0 · 0%

Acetone-based total-etch adhesive vs Calcium hydroxide (CH)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
up to 24 months
No clinical failure in any participant (Demir 2007); not estimable (direct pulp capping)
1 study · 40 participants
GRADE not reported

Endoflas (CH + ZOE + iodoform) vs Zinc oxide and eugenol (ZOE)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Endoflas (CH + ZOE + iodoform) showed no clear difference in clinical failure compared with zinc oxide and eugenol (ZOE) (moderate certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 months
RR 0.26 [0.05, 1.50]
2 studies · 80 participants
Moderate

Metapex (calcium hydroxide/iodoform) vs Endoflas chlorophenol free (Endoflas-CF)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Metapex (calcium hydroxide/iodoform) showed no clear difference in clinical failure compared with endoflas chlorophenol free (Endoflas-CF); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 1.00 [0.16, 6.25]
1 study · 32 participants
GRADE not reported

3Mix (ciprofloxacin + metronidazole + minocycline) vs 3Mixtatin

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

3Mix (ciprofloxacin + metronidazole + minocycline) may leads to higher clinical failure compared with 3Mixtatin (low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 4.00 [1.22, 13.11]
1 study · 160 participants
Low

Diode laser + mineral trioxide aggregate (MTA) vs Formocresol (FC) + zinc oxide and eugenol (ZOE)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
mean 15.7 months
No clinical failure in any participant (Saltzman 2005); not estimable
1 study · 52 participants
GRADE not reported

Metapex (calcium hydroxide/iodoform) vs Full strength formocresol (FC)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Calcium hydroxide/iodoform (CH/iodoform) led to higher clinical failure compared with full strength formocresol (FC); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 9.11 [3.04, 27.31]
1 study · 67 participants
GRADE not reported

Portland cement (PC) vs EMD (enamel matrix derivative) alone

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Portland cement (PC) showed no clear difference in clinical failure compared with enamel matrix derivative (EMD); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6, 12 and 24 months
RR 0.67 [0.12, 3.75]
1 study · 70 participants
GRADE not reported

Vitapex (calcium hydroxide/iodoform) vs 3Mix (ciprofloxacin + metronidazole + minocycline)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Vitapex (calcium hydroxide/iodoform) showed no clear difference in clinical failure compared with 3Mix (ciprofloxacin + metronidazole + minocycline); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 1.00 [0.07, 15.12]
1 study · 50 participants
GRADE not reported

Metapex (calcium hydroxide/iodoform) vs Endoflas (CH + ZOE + iodoform)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Metapex (calcium hydroxide/iodoform) showed no clear difference in clinical failure compared with endoflas (CH + ZOE + iodoform); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 months
RR 0.33 [0.01, 7.58]
2 studies · 92 participants
GRADE not reported

Tempophore vs Mineral trioxide aggregate (MTA)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Tempophore showed no clear difference in clinical failure compared with mineral trioxide aggregate (MTA); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 and 12 months
RR 3.21 [0.14, 75.68]
1 study · 56 participants
GRADE not reported

Electrosurgery vs Formocresol (FC)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Electrosurgery showed no clear difference in clinical failure compared with formocresol (FC); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
9 months
RR 3.00 [0.13, 71.22]
1 study · 70 participants
GRADE not reported

Vitapex (calcium hydroxide/iodoform) vs Zinc oxide and eugenol (ZOE)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Vitapex (calcium hydroxide/iodoform) may leads to higher clinical failure compared with zinc oxide and eugenol (ZOE) (low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 4.75 [1.21, 18.55]
4 studies · 161 participants
Low

Mineral trioxide aggregate (MTA) vs Sodium hypochlorite (NaOCl)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Mineral trioxide aggregate (MTA) showed no clear difference in clinical failure compared with sodium hypochlorite (NaOCl); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
24 months
RR 0.33 [0.01, 7.81]
1 study · 50 participants
GRADE not reported

Ferric sulphate (FS) vs Ankaferd Blood Stopper (ABS)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether ferric sulphate (FS) changes clinical failure compared with ankaferd Blood Stopper (ABS) (very low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 1.25 [0.37, 4.27]
2 studies · 100 participants
Very low

Vitapex (calcium hydroxide/iodoform) vs Calcium hydroxide (CH)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Vitapex (calcium hydroxide/iodoform) showed no clear difference in clinical failure compared with calcium hydroxide (CH); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 0.11 [0.01, 1.94]
1 study · 40 participants
GRADE not reported

Biodentine vs Formocresol (FC)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 months
No clinical failure in any participant (El Meligy 2016); not estimable
1 study · 112 participants
GRADE not reported

Metapex (calcium hydroxide/iodoform) vs Zinc oxide and eugenol (ZOE)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Metapex (calcium hydroxide/iodoform) showed no clear difference in clinical failure compared with zinc oxide and eugenol (ZOE) (moderate certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 0.71 [0.15, 3.33]
2 studies · 62 participants
Moderate

Erbium:YAG laser vs Calcium hydroxide (CH)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Erbium:YAG laser showed no clear difference in clinical failure compared with calcium hydroxide (CH); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
24 months
RR 0.62 [0.11, 3.56]
1 study · 91 participants
GRADE not reported

Bee propolis (one 500 mg capsule per day) vs Mineral trioxide aggregate (MTA)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Propolis showed no clear difference in clinical failure compared with mineral trioxide aggregate (MTA); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 months
RR 3.00 [0.13, 70.30]
1 study · 50 participants
GRADE not reported

Calcium hydroxide (CH) vs Zinc oxide and eugenol (ZOE)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Calcium hydroxide (CH) showed no clear difference in clinical failure compared with zinc oxide and eugenol (ZOE); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 9.00 [0.52, 156.92]
1 study · 40 participants
GRADE not reported