Clinical attachment level (CAL) · Adults with aggressive periodontitis
Doxycycline + SRP showed no clear difference in clinical attachment level (CAL) compared with metronidazole + SRP; GRADE not reported.
3 findings from 1 review
MD 0.34 [-0.08, 0.76]
3 studies · 75 participants
GRADE not reported
MD 1.10 [0.36, 1.84]
1 study · 27 participants
Very low
MD -0.12 [-0.72, 0.49]
2 studies · 49 participants
GRADE not reported
Clinical attachment level (CAL) · Adults with aggressive periodontitis
It is very uncertain whether doxycycline + SRP changes clinical attachment level (CAL) compared with SRP (very low certainty).
3 findings from 1 review
MD -0.80 [-1.49, -0.11]
1 study · 22 participants
Very low
MD -0.61 [-1.14, -0.08]
3 studies · 65 participants
GRADE not reported
MD 0.15 [-0.53, 0.83]
2 studies · 43 participants
GRADE not reported
Clinical attachment level (CAL) · Adults with aggressive periodontitis
Amoxicillin + metronidazole + SRP showed no clear difference in clinical attachment level (CAL) compared with clarithromycin + SRP; GRADE not reported.
2 findings from 1 review
Clinical attachment level (CAL) · Adults with aggressive periodontitis
It is very uncertain whether clindamycin + SRP changes clinical attachment level (CAL) compared with doxycycline + SRP (very low certainty).
3 findings from 1 review
MD -0.90 [-1.62, -0.18]
1 study · 23 participants
Very low
MD -0.40 [-1.15, 0.35]
1 study · 23 participants
GRADE not reported
MD 0.50 [-0.26, 1.26]
1 study · 23 participants
GRADE not reported
Clinical attachment level (CAL) · Adults with aggressive periodontitis
Tetracycline + SRP led to lower clinical attachment level (CAL) compared with SRP; GRADE not reported.
3 findings from 1 review
MD -1.90 [-2.17, -1.63]
1 study · 26 participants
GRADE not reported
MD -2.30 [-2.50, -2.10]
1 study · 26 participants
Very low
MD -0.92 [-2.38, 0.54]
2 studies · 64 participants
GRADE not reported
Clinical attachment level (CAL) · Adults with aggressive periodontitis
Clindamycin + SRP led to lower clinical attachment level (CAL) compared with SRP; GRADE not reported.
3 findings from 1 review
MD -1.30 [-2.14, -0.46]
1 study · 21 participants
GRADE not reported
MD 0.40 [-0.35, 1.15]
1 study · 21 participants
GRADE not reported
MD -1.70 [-2.40, -1.00]
1 study · 21 participants
Very low
Clinical attachment level (CAL) · Adults with aggressive periodontitis
Doxycycline + SRP showed no clear difference in clinical attachment level (CAL) compared with amoxicillin + metronidazole + SRP; GRADE not reported.
2 findings from 1 review
Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive)
Clarithromycin + SRP led to lower clinical attachment level (CAL) compared with SRP; GRADE not reported.
2 findings from 1 review
Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive)
Metronidazole + SRP showed no clear difference in clinical attachment level (CAL) compared with amoxicillin + metronidazole + SRP; GRADE not reported.
2 findings from 1 review
Clinical attachment level (CAL) · Adults with chronic periodontitis
Cefixime + SRP showed no clear difference in clinical attachment level (CAL) compared with SRP; GRADE not reported.
1 finding from 1 review
Clinical attachment level (CAL) · Adults with chronic periodontitis
Amoxicillin + clavulanate + SRP showed no clear difference in clinical attachment level (CAL) compared with SRP; GRADE not reported.
3 findings from 1 review
MD 0.10 [-0.45, 0.65]
1 study · 21 participants
GRADE not reported
MD 0.10 [-0.51, 0.71]
1 study · 21 participants
Very low
MD 0.10 [-0.43, 0.63]
1 study · 21 participants
GRADE not reported
Clinical attachment level (CAL) · Adults with aggressive periodontitis
Clindamycin + SRP showed no clear difference in clinical attachment level (CAL) compared with metronidazole + SRP; GRADE not reported.
3 findings from 1 review
MD 0.40 [-0.22, 1.02]
1 study · 26 participants
GRADE not reported
MD 0.20 [-0.55, 0.95]
1 study · 26 participants
Very low
MD 0.10 [-0.60, 0.80]
1 study · 26 participants
GRADE not reported
Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive)
It is very uncertain whether amoxicillin + metronidazole + SRP changes clinical attachment level (CAL) compared with SRP (very low certainty).
3 findings from 1 review
MD -0.47 [-0.90, -0.05]
2 studies · 389 participants
Very low
MD -0.21 [-0.41, -0.01]
13 studies · 501 participants
GRADE not reported
MD -0.04 [-0.35, 0.26]
6 studies · 215 participants
GRADE not reported
Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive)
It is very uncertain whether azithromycin + SRP changes clinical attachment level (CAL) compared with SRP (very low certainty).
3 findings from 1 review
MD -0.59 [-1.27, 0.08]
2 studies · 110 participants
Very low
MD -0.43 [-0.77, -0.10]
7 studies · 258 participants
GRADE not reported
MD -0.51 [-0.83, -0.19]
6 studies · 216 participants
GRADE not reported
Clinical attachment level (CAL) · Adults with chronic periodontitis
Moxifloxacin + SRP led to lower clinical attachment level (CAL) compared with SRP; GRADE not reported.
2 findings from 1 review
Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive)
Metronidazole + SRP showed no clear difference in clinical attachment level (CAL) compared with SRP; GRADE not reported.
3 findings from 1 review
MD 0.04 [-0.43, 0.50]
4 studies · 108 participants
GRADE not reported
MD -1.12 [-2.24, 0.00]
3 studies · 71 participants
Very low
MD -0.49 [-1.29, 0.31]
4 studies · 94 participants
GRADE not reported
Clinical attachment level (CAL) · Adults with chronic periodontitis
Levofloxacin + SRP led to lower clinical attachment level (CAL) compared with SRP; GRADE not reported.
2 findings from 1 review