Findings

What do systematic reviews say?

5 questions · 5 findings · 2 reviews · Dental caries

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No studies found 0 · 0%GRADE not reported 5 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Platelet-rich fibrin (PRF) graft vs Mineral trioxide aggregate (MTA)

Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in immature permanent teeth undergoing pulpotomy

The two trials of PRF versus MTA for success gave contradictory results and were not pooled (ungraded).

1 finding from 1 review

Comparative efficacy of materials used in patients undergoing pulpotomy or direct pulp capping in carious teeth: A… 2023 All outcomes
≥6 months follow-up · Dental/endodontic clinical settings across multiple countries (university, hospital, specialist and general dental practice); permanent teeth with carious pulp exposure
PRF vs MTA was investigated in 2 RCTs (Alawwad 2020; Keswani 2014) for the primary outcome; the two trials provided contradictory evidence and differed in risk of bias, so were not pooled. Weak evidence.
2 studies
GRADE not reported

Calcium-enriched mixture (CEM) cement vs Mineral trioxide aggregate (MTA)

Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in permanent teeth undergoing pulpotomy

MTA and CEM performed comparably for clinical and radiographic success (2 RCTs, not pooled; ungraded).

1 finding from 1 review

Comparative efficacy of materials used in patients undergoing pulpotomy or direct pulp capping in carious teeth: A… 2023 All outcomes
≥6 months follow-up · Dental/endodontic clinical settings across multiple countries (university, hospital, specialist and general dental practice); permanent teeth with carious pulp exposure
CEM vs MTA was investigated in 2 RCTs (Asgary 2017; Nosrat 2013) for the primary outcome; not pooled owing to heterogeneity. The per-trial forest plots (Figure 8) indicated MTA performed comparably to CEM. Weak evidence.
2 studies
GRADE not reported

Platelet-rich fibrin (PRF) graft vs Calcium hydroxide (CH)

Overall success (composite of clinical and radiographic success) · Mature permanent teeth with irreversible pulpitis and carious pulp exposure (treated with full pulpotomy)

Platelet-rich fibrin and calcium hydroxide showed no significant difference in success (ungraded; effect size not reported).

1 finding from 1 review

Efficacy of pulpotomy for permanent teeth with carious pulp exposure: A systematic review and meta-analysis of… 2024 All outcomes
>=12 months
OR 1.67 [0.59, 4.72]
2 studies · 70 participants
GRADE not reported

Mineral trioxide aggregate (MTA) vs Calcium-enriched mixture (CEM)

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure

MTA and calcium-enriched mixture had comparable pulpotomy success (ungraded).

1 finding from 1 review

Efficacy of pulpotomy for permanent teeth with carious pulp exposure: A systematic review and meta-analysis of… 2024 All outcomes
>=12 months
OR 0.78 [0.46, 1.34]
4 studies · 611 participants
GRADE not reported

Mineral trioxide aggregate (MTA) vs Platelet-rich fibrin (PRF)

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure

MTA and platelet-rich fibrin had comparable pulpotomy success (ungraded).

1 finding from 1 review

Efficacy of pulpotomy for permanent teeth with carious pulp exposure: A systematic review and meta-analysis of… 2024 All outcomes
>=12 months
OR 1.02 [0.43, 2.43]
3 studies · 109 participants
GRADE not reported