Findings

What do systematic reviews say?

3 questions · 4 findings · 2 reviews · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 4 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Any systemic treatment vs placebo

Ciclosporin · people with chronic plaque psoriasis

It is very uncertain whether any systemic treatment changes ciclosporin compared with placebo (very low certainty).

2 findings from 1 review

Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis 2020 · Cochrane Headline outcomes only
RR 9.88 [5.45, 17.91]
0 studies · 0 participants
Very low
Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis 2020 · Cochrane Headline outcomes only
RR 1.47 [0.19, 11.22]
0 studies · 0 participants
Very low

Methotrexate vs other DMARDs

Serious adverse events (ciclosporin A) assessed by number of events · psoriatic arthritis

1 finding from 1 review

Methotrexate for psoriatic arthritis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 35 participants
Very low

Methotrexate vs other DMARDs

Withdrawals due to adverse events · psoriatic arthritis

It is very uncertain whether methotrexate changes withdrawals due to adverse events (ciclosporin A) assessed by number… compared with other DMARDs (very low certainty).

1 finding from 1 review

Methotrexate for psoriatic arthritis 2019 · Cochrane Headline outcomes only
RR 1.26 [0.33, 4.82]
1 study · 35 participants
Very low