Valproate vs lithiumChange in symptom severity at 3 weeks (secondary efficacy outcome) · Adults (aged 18 and over) with acute mania1 finding from 1 reviewValproate for acute mania 2019 · Cochrane Headline outcomes onlyno estimate extracted2 studies · 57 participantsVery low
Valproate vs OLANZAPINEChange in symptom severity at 3 weeks (secondary efficacy outcome) · Adults (aged 18 and over) with acute mania1 finding from 1 reviewValproate for acute mania 2019 · Cochrane Headline outcomes onlyno estimate extracted4 studies · 826 participantsHigh
Valproate vs placeboChange in symptom severity at 3 weeks (secondary efficacy outcome) · Adults (aged 18 and over) with acute mania1 finding from 1 reviewValproate for acute mania 2019 · Cochrane Headline outcomes onlyno estimate extracted4 studies · 907 participantsModerate
Valproate vs placeboChange in symptom severity at 3 weeks (secondary efficacy outcome) · Children and adolescents with acute mania1 finding from 1 reviewValproate for acute mania 2019 · Cochrane Headline outcomes onlyno estimate extracted1 study · 144 participantsVery low
Valproate vs RISPERIDONEChange in symptom severity at 5 ‐ 12 weeks (secondary efficacy outcome) · Children and adolescents with acute mania1 finding from 1 reviewValproate for acute mania 2019 · Cochrane Headline outcomes onlyno estimate extracted2 studies · 228 participantsLow
Valproate vs lithiumChange in symptom severity of mania rating scale at 8 weeks (secondary efficacy outcome) · Children and adolescents with acute mania1 finding from 1 reviewValproate for acute mania 2019 · Cochrane Headline outcomes onlyno estimate extracted1 study · 190 participantsVery low