Findings

What do systematic reviews say?

15 questions · 15 findings · 3 reviews · Dental caries

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No studies found 0 · 0%GRADE not reported 14 · 93.3%Very low 0 · 0%Low 0 · 0%Moderate 1 · 6.7%High 0 · 0%

Fluoride gel combined with fluoride mouthrinse vs Fluoride mouthrinse

Caries increment on permanent tooth surfaces (D(M)FS), prevented fraction · Children and adolescents aged 16 years or less

1 finding from 1 review

Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes
Nearest to 3 years
PF 0.02 [-0.20, 0.24]
1 study · 252 participants
GRADE not reported

Fluoride mouthrinse (0.05-0.32% sodium fluoride or amine fluoride) added to daily fluoride toothpaste vs Fluoride mouthrinse

Caries increment on permanent tooth surfaces (D(M)FS), prevented fraction · Children and adolescents aged 16 years or less

1 finding from 1 review

Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes
Nearest to 3 years
PF 0.05 [-0.05, 0.15]
4 studies · 1678 participants
GRADE not reported

Fluoride gel (topically applied; operator- or self-applied; any fluoride agent/concentration; frequency at least once a year) vs Fluoride mouthrinse

Caries increment in permanent teeth · Children and adolescents aged 16 years or less

1 finding from 1 review

One topical fluoride (toothpastes, or mouthrinses, or gels, or varnishes) versus another for preventing dental caries… 2004 · Cochrane All outcomes
1 to 3 years (final follow-up)
PF -0.14 [-0.40, 0.12]
1 study · 257 participants
GRADE not reported

Fluoride varnish vs Fluoride mouthrinse

Caries increment in permanent teeth · Children and adolescents aged 16 years or less

1 finding from 1 review

One topical fluoride (toothpastes, or mouthrinses, or gels, or varnishes) versus another for preventing dental caries… 2004 · Cochrane All outcomes
1 to 3 years (final follow-up)
PF 0.10 [-0.12, 0.32]
4 studies · 952 participants
GRADE not reported

Fluoride gel combined with fluoride mouthrinse vs Fluoride gel

Caries increment on permanent tooth surfaces (D(M)FS), prevented fraction · Children and adolescents aged 16 years or less

1 finding from 1 review

Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes
Nearest to 3 years
PF 0.23 [0.04, 0.43]
2 studies · 497 participants
GRADE not reported

Fluoride mouthrinse (0.05-0.32% sodium fluoride or amine fluoride) added to daily fluoride toothpaste vs Fluoride toothpaste alone

Caries increment on permanent tooth surfaces (D(M)FS), prevented fraction · Children and adolescents aged 16 years or less

1 finding from 1 review

Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes
Nearest to 3 years
PF 0.07 [0.00, 0.13]
5 studies · 2738 participants
GRADE not reported

Fluoride toothpaste vs Fluoride mouthrinse

Caries increment in permanent teeth · Children and adolescents aged 16 years or less

1 finding from 1 review

One topical fluoride (toothpastes, or mouthrinses, or gels, or varnishes) versus another for preventing dental caries… 2004 · Cochrane All outcomes
1 to 3 years (final follow-up)
PF 0.00 [-0.18, 0.19]
6 studies · 2545 participants
GRADE not reported

Fluoride toothpaste vs Any other topical fluoride (gel or mouthrinse)

Caries increment in permanent teeth · Children and adolescents aged 16 years or less

1 finding from 1 review

One topical fluoride (toothpastes, or mouthrinses, or gels, or varnishes) versus another for preventing dental caries… 2004 · Cochrane All outcomes
1 to 3 years (final follow-up)
PF 0.01 [-0.13, 0.14]
9 studies · 3801 participants
GRADE not reported

Fluoride mouthrinse, gel or varnish combined with fluoride toothpaste (any combined regimen) vs Fluoride toothpaste alone

Caries increment on permanent tooth surfaces (D(M)FS), prevented fraction · Children and adolescents aged 16 years or less

1 finding from 1 review

Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes
Nearest to 3 years
PF 0.10 [0.02, 0.17]
9 studies · 4026 participants
GRADE not reported

Fluoride varnish vs Fluoride gel

Caries increment in permanent teeth · Children and adolescents aged 16 years or less

1 finding from 1 review

One topical fluoride (toothpastes, or mouthrinses, or gels, or varnishes) versus another for preventing dental caries… 2004 · Cochrane All outcomes
1 to 3 years (final follow-up)
PF 0.14 [-0.12, 0.40]
1 study · 254 participants
GRADE not reported

Fluoride toothpaste vs Fluoride gel

Caries increment in permanent teeth · Children and adolescents aged 16 years or less

1 finding from 1 review

One topical fluoride (toothpastes, or mouthrinses, or gels, or varnishes) versus another for preventing dental caries… 2004 · Cochrane All outcomes
1 to 3 years (final follow-up)
PF 0.00 [-0.21, 0.21]
3 studies · 1256 participants
GRADE not reported

Fluoride mouthrinse (any fluoride agent, concentration, volume, frequency or technique; swished and expectorated, not swallowed) vs placebo or no treatment

Caries increment on permanent tooth surfaces (D(M)FS), prevented fraction · Children and adolescents aged 16 years or less

1 finding from 1 review

Fluoride mouthrinses for preventing dental caries in children and adolescents 2016 · Cochrane All outcomes
At least 1 year/school year
PF 0.27 [0.23, 0.30]
35 studies · 15305 participants
Moderate

Fluoride gel combined with fluoride toothpaste vs Fluoride gel

Caries increment on permanent tooth surfaces (D(M)FS), prevented fraction · Children and adolescents aged 16 years or less

1 finding from 1 review

Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes
Nearest to 3 years
PF 0.10 [-0.01, 0.21]
3 studies · 759 participants
GRADE not reported

Fluoride gel combined with fluoride toothpaste vs Fluoride toothpaste alone

Caries increment on permanent tooth surfaces (D(M)FS), prevented fraction · Children and adolescents aged 16 years or less

1 finding from 1 review

Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes
Nearest to 3 years
PF 0.14 [-0.09, 0.38]
3 studies · 1217 participants
GRADE not reported

Fluoride varnish combined with fluoride toothpaste vs Fluoride toothpaste alone

Caries increment on permanent tooth surfaces (D(M)FS), prevented fraction · Children and adolescents aged 16 years or less

1 finding from 1 review

Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes
Nearest to 3 years
PF 0.48 [0.12, 0.84]
1 study · 71 participants
GRADE not reported