What do systematic reviews say?

Metoprolol vs placebo

Metoprolol showed no clear difference in cardiovascular death, 6 months3 compared with placebo (low certainty).

• Pharmacological treatment of vascular risk factors for reducing mortality and cardiovascular events in patients with… 2017 · Cochrane Headline outcomes only
  OR 0.73 [0.23, 2.39]
  1 study · 227 participants
  Low