Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews · Breast Cancer

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 2 · 100%High 0 · 0%

Bone metastases · women with early breast cancer

Bisphosphonates probably leads to lower bone metastases compared with placebo/observation (moderate certainty).

1 finding from 1 review

Bisphosphonates and other bone agents for breast cancer 2017 · Cochrane Headline outcomes only
RR 0.86 [0.75, 0.99]
11 studies · 15005 participants
Moderate

Bone metastases · women with advanced breast cancer without bone metastases

Bisphosphonates showed no clear difference in bone metastases compared with placebo/observation (moderate certainty).

1 finding from 1 review

Bisphosphonates and other bone agents for breast cancer 2017 · Cochrane Headline outcomes only
RR 0.96 [0.65, 1.43]
3 studies · 330 participants
Moderate