Findings

What do systematic reviews say?

8 questions · 8 findings · 4 reviews · Pregnancy and Childbirth

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No studies found 2 · 25%GRADE not reported 0 · 0%Very low 2 · 25%Low 2 · 25%Moderate 1 · 12.5%High 1 · 12.5%

Oxytocin vs ergot alkaloids

Blood transfusion · women in the third stage of labour

It is very uncertain whether oxytocin changes blood transfusion compared with ergot alkaloids (very low certainty).

1 finding from 1 review

Prophylactic oxytocin for the third stage of labour to prevent postpartum haemorrhage 2019 · Cochrane Headline outcomes only
RR 1.37 [0.34, 5.51]
7 studies · 1578 participants
Very low

Oxytocin vs no uterotonics or placebo

Blood transfusion · women in the third stage of labour

Oxytocin showed no clear difference in blood transfusion compared with no uterotonics or placebo (low certainty).

1 finding from 1 review

Prophylactic oxytocin for the third stage of labour to prevent postpartum haemorrhage 2019 · Cochrane Headline outcomes only
RR 0.88 [0.44, 1.78]
3 studies · 3081 participants
Low

Oxytocin + ergometrine vs ergot alkaloids

Blood transfusion · women in the third stage of labour

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic oxytocin for the third stage of labour to prevent postpartum haemorrhage 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oxytocin solution vs expectant management

Blood transfusion · management of retained placenta

Oxytocin solution showed no clear difference in blood transfusion compared with expectant management (low certainty).

1 finding from 1 review

Umbilical vein injection for management of retained placenta 2021 · Cochrane Headline outcomes only
RR 0.81 [0.47, 1.38]
4 studies · 339 participants
Low

Oxytocin solution vs Normal saline

Blood transfusion · management of retained placenta

Oxytocin solution showed no clear difference in blood transfusion compared with saline solution (moderate certainty).

1 finding from 1 review

Umbilical vein injection for management of retained placenta 2021 · Cochrane Headline outcomes only
RR 1.08 [0.78, 1.49]
7 studies · 974 participants
Moderate

Oxytocin solution vs plasma expander

Blood transfusion · management of retained placenta

The review found no eligible studies for this question.

1 finding from 1 review

Umbilical vein injection for management of retained placenta 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intravenous vs intramuscular oxytocin

Blood transfusion · women in the 3rd stage of labour undergoing a vaginal birth.

Intravenous leads to lower blood transfusion compared with intramuscular oxytocin (high certainty).

1 finding from 1 review

Intravenous versus intramuscular prophylactic oxytocin for reducing blood loss in the third stage of labour 2020 · Cochrane Headline outcomes only
RR 0.44 [0.26, 0.77]
4 studies · 6684 participants
High

Intrauterine balloon tamponade plus normal care (misoprostol) vs normal care (misoprostol)

Blood transfusion (red cell or whole blood) · women diagnosed with primary PPH following vaginal birth. Women were suspected to have PPH due to clinical atony and who were quote:…

It is very uncertain whether intrauterine balloon tamponade plus normal care (misoprostol) changes blood transfusion (red cell or whole blood) compared with normal care (misoprostol) (very low certainty).

1 finding from 1 review

Mechanical and surgical interventions for treating primary postpartum haemorrhage 2020 · Cochrane Headline outcomes only
RR 1.49 [0.88, 2.51]
1 study · 116 participants
Very low