Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

15 questions · 15 findings · 1 reviews · Drugs and Alcohol

No studies found 0 · 0%GRADE not reported 2 · 13.3%Very low 8 · 53.3%Low 5 · 33.3%Moderate 0 · 0%High 0 · 0%

Valproate vs placebo or no intervention

Benzodiazepine discontinuation, end of intervention · adults who withdraw from chronic benzodiazepine use

It is very uncertain whether valproate changes benzodiazepine discontinuation, end of intervention compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Paroxetine vs placebo or no intervention

Benzodiazepine discontinuation, end of intervention · adults who withdraw from chronic benzodiazepine use

It is very uncertain whether paroxetine changes benzodiazepine discontinuation, end of intervention compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Tricyclic antidepressants vs placebo

Benzodiazepine discontinuation, end of intervention · adults who withdraw from chronic benzodiazepine use

It is very uncertain whether tricyclic antidepressants changes benzodiazepine discontinuation, end of intervention compared with placebo (very low certainty).

1 finding from 1 review

Magnesium aspartate vs placebo

Benzodiazepine discontinuation, end of intervention · adults who withdraw from chronic benzodiazepine use

It is very uncertain whether magnesium aspartate changes benzodiazepine discontinuation, end of intervention compared with placebo (very low certainty).

1 finding from 1 review

Homéogène 46/Sedatif PC (homeopathic drugs) vs placebo

Benzodiazepine discontinuation, end of intervention · adults who withdraw from chronic benzodiazepine use

It is very uncertain whether homéogène 46/Sedatif PC (homeopathic drugs) changes benzodiazepine discontinuation, end of intervention compared with placebo (very low certainty).

1 finding from 1 review

Carbamazepine vs tricyclic antidepressants (TCAs)

Benzodiazepine discontinuation, end of intervention · adults who withdraw from chronic benzodiazepine use

Carbamazepine showed no clear difference in benzodiazepine discontinuation, end of intervention compared with tricyclic antidepressant (low certainty).

1 finding from 1 review