Findings

What do systematic reviews say?

5 questions · 5 findings · 1 reviews · Cystic Fibrosis and Genetic Disorders

No studies found 2 · 40%GRADE not reported 0 · 0%Very low 1 · 20%Low 1 · 20%Moderate 1 · 20%High 0 · 0%

BMD Z score (total hip/femoral neck) · adults with β‐thalassaemia and osteoporosis

The review found no eligible studies for this question.

1 finding from 1 review

Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

BMD Z score (total hip/femoral neck) · children and adults with β‐thalassaemia major and low bone mass

Summary of findings – zinc probably leads to higher BMD Z score (total hip/femoral neck) compared with placebo (moderate certainty).

1 finding from 1 review

Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
MD 0.15 [0.11, 0.19]
1 study · 37 participants
Moderate

BMD Z score (total hip/femoral neck) · adults with β‐thalassaemia and low bone mass

Summary of findings – denosumab showed no clear difference in BMD Z score (total hip/femoral neck) compared with placebo (low certainty).

1 finding from 1 review

Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
MD 0.05
1 study · 63 participants
Low

BMD Z score (total hip/femoral neck) · women with low bone mass and β‐thalassaemia

The review found no eligible studies for this question.

1 finding from 1 review

Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

BMD Z score (total hip/femoral neck) · people with β‐thalassaemia and osteoporosis

It is very uncertain whether the intervention changes BMD Z score (total hip/femoral neck) (very low certainty).

1 finding from 1 review

Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 26 participants
Very low