Findings

What do systematic reviews say?

4 questions · 7 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 2 · 28.6%Very low 3 · 42.9%Low 1 · 14.3%Moderate 1 · 14.3%High 0 · 0%

Adults: formoterol/ICS vs salmeterol/ICS

Asthma‐related non‐fatal serious adverse events · adults, chronic asthma: all‐cause mortality

Adults: formoterol/ICS showed no clear difference in asthma‐related non‐fatal serious adverse events ‐… compared with salmeterol/ICS (low certainty).

4 findings from 1 review

Regular treatment with formoterol and an inhaled corticosteroid versus regular treatment with salmeterol and an… 2021 · Cochrane Headline outcomes only
OR 0.69 [0.37, 1.26]
7 studies · 5935 participants
Low
Regular treatment with formoterol and an inhaled corticosteroid versus regular treatment with salmeterol and an… 2021 · Cochrane Headline outcomes only
OR 1.01 [0.06, 16.24]
5 studies · 1510 participants
Very low
Regular treatment with formoterol and an inhaled corticosteroid versus regular treatment with salmeterol and an… 2021 · Cochrane Headline outcomes only
OR 0.05 [0, 3.1]
2 studies · 293 participants
Very low

Show 1 more finding

Regular treatment with formoterol and an inhaled corticosteroid versus regular treatment with salmeterol and an… 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 229 participants
GRADE not reported

Regular formoterol and ICS vs same‐dose ICS

Asthma‐related non‐fatal serious adverse events · adults, chronic asthma: all‐cause mortality

Regular formoterol and ICS showed no clear difference in asthma‐related non‐fatal serious adverse events compared with same‐dose ICS (moderate certainty).

1 finding from 1 review

Inhaled steroids with and without regular formoterol for asthma: serious adverse events 2019 · Cochrane Headline outcomes only
OR 0.86 [0.64, 1.14]
30 studies · 35158 participants
Moderate

Regular formoterol and ICS vs same‐dose ICS

Asthma‐related non‐fatal serious adverse events · children and adolescents with chronic asthma

It is very uncertain whether regular formoterol and ICS changes asthma‐related non‐fatal serious adverse events compared with same‐dose ICS (very low certainty).

1 finding from 1 review

Inhaled steroids with and without regular formoterol for asthma: serious adverse events 2019 · Cochrane Headline outcomes only
OR 1.18 [0.4, 3.51]
10 studies · 4035 participants
Very low

Children: formoterol/fluticasone vs regular salmeterol and fluticasone

Asthma‐related non‐fatal serious adverse events · children with chronic asthma

1 finding from 1 review

Regular treatment with formoterol and an inhaled corticosteroid versus regular treatment with salmeterol and an… 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 548 participants
GRADE not reported