Findings

What do systematic reviews say?

5 questions · 5 findings · 3 reviews · Gut

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 3 · 60%Low 0 · 0%Moderate 0 · 0%High 2 · 40%

Biological therapy vs placebo, best supportive care (BSC) or no treatment

Any adverse events · advanced gastric and oesophago‐gastric junction adenocarcinoma

Biological therapy showed no clear difference in any adverse events compared with placebo, best supportive care (BSC) or no treatment (high certainty).

1 finding from 1 review

Salvage systemic therapy for advanced gastric and oesophago‐gastric junction adenocarcinoma 2020 · Cochrane Headline outcomes only
RR 1.08 [1, 1.17]
1 study · 491 participants
High

Chemotherapy vs placebo, best supportive care (BSC) or no treatment

Any adverse events · advanced gastric and oesophago‐gastric junction adenocarcinoma

Chemotherapy showed no clear difference in any adverse events compared with placebo, best supportive care (BSC) or no treatment (high certainty).

1 finding from 1 review

Salvage systemic therapy for advanced gastric and oesophago‐gastric junction adenocarcinoma 2020 · Cochrane Headline outcomes only
RR 1.04 [1, 1.09]
1 study · 503 participants
High

Azathioprine vs placebo

Any adverse events · Patients with quiescent ulcerative colitis

It is very uncertain whether azathioprine changes any adverse events compared with placebo (very low certainty).

1 finding from 1 review

Azathioprine and 6‐mercaptopurine for maintenance of remission in ulcerative colitis 2016 · Cochrane Headline outcomes only
RR 2.51 [0.82, 7.74]
4 studies · 232 participants
Very low

Synbiotic vs placebo

Adverse events (any) · children (4 to 18 years) with functional abdominal pain disorders

It is very uncertain whether synbiotic changes adverse events (any) compared with placebo (very low certainty).

1 finding from 1 review

Probiotics for management of functional abdominal pain disorders in children 2023 · Cochrane Headline outcomes only
RR 2.88 [0.32, 25.92]
3 studies · 189 participants
Very low

Probiotics vs placebo

Adverse events (any) · children (4 to 18 years) with functional abdominal pain disorders

It is very uncertain whether probiotic changes adverse events (any) compared with placebo (very low certainty).

1 finding from 1 review

Probiotics for management of functional abdominal pain disorders in children 2023 · Cochrane Headline outcomes only
RR 1 [0.07, 15.12]
7 studies · 489 participants
Very low