Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 1 · 33.3%High 2 · 66.7%

28 days on/off antibiotic regimen vs 28 days on/off placebo regimen

Antibiotic resistance · people with bronchiectasis

28 days on/off antibiotic regimen leads to higher antibiotic resistance compared with 28 days on/off placebo regimen (high certainty).

1 finding from 1 review

Intermittent prophylactic antibiotics for bronchiectasis 2022 · Cochrane Headline outcomes only
OR 2.2 [1.42, 3.42]
Studies not reported
High

14 days on/off antibiotic regimen vs 28 days on/off antibiotic regimen

Antibiotic resistance · people with bronchiectasis

14 days on/off antibiotic regimen showed no clear difference in antibiotic resistance compared with 28 days on/off antibiotic regimen (moderate certainty).

1 finding from 1 review

Intermittent prophylactic antibiotics for bronchiectasis 2022 · Cochrane Headline outcomes only
OR 1 [0.68, 1.48]
Studies not reported
Moderate

14 days on/off antibiotic regimen vs 14 days on/off placebo regimen

Antibiotic resistance · people with bronchiectasis

14 days on/off antibiotic regimen leads to higher antibiotic resistance compared with 14 days on/off placebo regimen (high certainty).

1 finding from 1 review

Intermittent prophylactic antibiotics for bronchiectasis 2022 · Cochrane Headline outcomes only
OR 2.14 [1.36, 3.35]
Studies not reported
High