Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews · Emergency and Critical Care

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 2 · 100%High 0 · 0%

Monoclonal antibodies vs placebo

Anti‐cytokine, all‐cause mortality ‐ uncertain risk of bias · patients with sepsis, severe sepsis, septic shock

Monoclonal antibodies probably leads to lower anti‐cytokines versus placebo, all‐cause mortality compared with placebo (moderate certainty).

1 finding from 1 review

Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock 2013 · Cochrane Headline outcomes only
RR 0.92 [0.86, 0.97]
9 studies · 7893 participants
Moderate

Monoclonal antibodies vs placebo

Anti‐cytokines ‐ human interleukin‐1receptor antagonist versus placebo, all‐cause mortality · patients with sepsis, severe sepsis, septic shock

Monoclonal antibodies showed no clear difference in anti‐cytokines ‐ human interleukin‐1receptor antagonist versus… compared with placebo (moderate certainty).

1 finding from 1 review

Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock 2013 · Cochrane Headline outcomes only
RR 0.88 [0.76, 1.01]
3 studies · 1693 participants
Moderate