Monoclonal antibodies vs placebo: Anti‐cytokine, all‐cause mortality ‐ uncertain risk of bias
Monoclonal antibodies probably leads to lower anti‐cytokines versus placebo, all‐cause mortality compared with placebo (moderate certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Monoclonal antibodies vs placebo Anti‐cytokines versus placebo, all‐cause mortality · patients with sepsis, severe sepsis, septic shock Monoclonal antibodies probably leads to lower anti‐cytokines versus placebo, all‐cause mortality compared with placebo (moderate certainty). Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock (2013) · Cochrane Headline outcomes only | RR 0.92 [0.86, 0.97] | 9 studies · 7893 participants | Moderate |
Monoclonal antibodies vs placebo Sensitivity analysis by quality, anti‐cytokine, all‐cause mortality · patients with sepsis, severe sepsis, septic shock Monoclonal antibodies probably leads to lower sensitivity analysis by quality, anti‐cytokine, all‐cause mortality compared with placebo (moderate certainty). Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock (2013) · Cochrane Headline outcomes only | RR 0.91 [0.86, 0.97] | 7 studies · 7752 participants | Moderate |
Monoclonal antibodies vs placebo Anti‐cytokine, all‐cause mortality ‐ uncertain risk of bias · patients with sepsis, severe sepsis, septic shock Monoclonal antibodies showed no clear difference in anti‐cytokine, all‐cause mortality ‐ uncertain risk of bias compared with placebo (moderate certainty). Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock (2013) · Cochrane Headline outcomes only | RR 0.89 [0.8, 1] | 4 studies · 2687 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock 2013 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.