Findings

What do systematic reviews say?

4 questions · 4 findings · 1 reviews · Vascular

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No studies found 0 · 0%GRADE not reported 1 · 25%Very low 1 · 25%Low 2 · 50%Moderate 0 · 0%High 0 · 0%

BM‐MNCs vs mPBSCs

Rate of amputation · people with critical limb ischaemia

BM‐MNCs showed no clear difference in amputation rate Assessed during in‐patient stay compared with mPBSCs (low certainty).

1 finding from 1 review

Autologous cells derived from different sources and administered using different regimens for 'no‐option' critical… 2018 · Cochrane Headline outcomes only
RR 1.54 [0.45, 5.24]
1 study · 150 participants
Low

IM injection vs IA injection

Rate of amputation · people with critical limb ischaemia

IM injection showed no clear difference in amputation rate Assessed during in‐patient stay compared with IA injection (low certainty).

1 finding from 1 review

Autologous cells derived from different sources and administered using different regimens for 'no‐option' critical… 2018 · Cochrane Headline outcomes only
RR 0.8 [0.54, 1.18]
3 studies · 95 participants
Low

BM‐MNCs vs BM‐MSCs

Rate of amputation · people with critical limb ischaemia

1 finding from 1 review

Autologous cells derived from different sources and administered using different regimens for 'no‐option' critical… 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 37 participants
GRADE not reported

High cell dose vs low cell dose

Rate of amputation · people with critical limb ischaemia

It is very uncertain whether high cell dose changes amputation rate Assessed during in‐patient stay (Losordo 2012) compared with low cell dose (very low certainty).

1 finding from 1 review

Autologous cells derived from different sources and administered using different regimens for 'no‐option' critical… 2018 · Cochrane Headline outcomes only
RR 3.21 [0.87, 11.9]
1 study · 16 participants
Very low