Findings

What do systematic reviews say?

5 questions · 13 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 6 · 46.2%Very low 0 · 0%Low 4 · 30.8%Moderate 1 · 7.7%High 2 · 15.4%

Edentulous (0 remaining teeth) vs 1-32 remaining teeth

All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies

In prospective cohorts, the multivariable-adjusted HR for all-cause mortality in edentulous adults (0 teeth) vs adults with 1-32 teeth was 1.30 (95% CI 1.21 to 1.40; 7 studies, I2=20%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).

4 findings from 1 review

Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report · Multivariable-adjusted
HR 1.30 [1.21, 1.40]
7 studies · 102254 participants
Moderate
Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report · Adjusted for age/sex
HR 1.56 [1.48, 1.65]
3 studies · 43734 participants
GRADE not reported
Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report
RR 1.94 [1.19, 3.15]
14 studies · 4711667 participants
Low

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Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report · Crude
HR 1.73 [1.41, 2.13]
5 studies · 99303 participants
GRADE not reported

0-19 remaining teeth vs 20-32 remaining teeth

All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies

In prospective cohorts, the crude HR for all-cause mortality in adults with 0-19 teeth vs adults with 20-32 teeth was 2.47 (95% CI 2.40 to 2.54; 2 studies, I2=0%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).

4 findings from 1 review

Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report · Crude
HR 2.47 [2.40, 2.54]
2 studies · 36379 participants
GRADE not reported
Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report
RR 1.84 [1.52, 2.23]
11 studies · 267575 participants
Low
Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report · Multivariable-adjusted
HR 1.29 [1.21, 1.37]
10 studies · 305970 participants
Low

Show 1 more finding

Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report · Adjusted for age/sex
HR 1.42 [1.15, 1.75]
5 studies · 212657 participants
GRADE not reported

Higher number of lost teeth (per one additional lost tooth) vs Fewer lost teeth (continuous, per-tooth increment)

All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies

Each additional lost tooth was associated with a multivariable-adjusted HR of 1.02 (95% CI 1.01 to 1.03) for all-cause mortality (11 studies, I2=89%), statistically significant; GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).

3 findings from 1 review

Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report · Multivariable-adjusted
HR 1.02 [1.01, 1.03]
11 studies · 4467321 participants
Low
Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report · Crude
HR 1.01 [1.00, 1.03]
3 studies · 2219 participants
GRADE not reported
Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report · Adjusted for age/sex
HR 1.02 [1.01, 1.04]
5 studies · 4421245 participants
GRADE not reported

1-19 remaining teeth vs 20-32 remaining teeth

All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies

In prospective cohorts, adults with 1-19 teeth had a higher cumulative incidence of all-cause mortality than adults with 20-32 teeth (RR 1.76, 95% CI 1.41 to 2.19; 8 cohort studies, I2=94%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).

1 finding from 1 review

Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report
RR 1.76 [1.41, 2.19]
8 studies · 222572 participants
High

Edentulous (0 remaining teeth) vs 20-32 remaining teeth

All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies

In prospective cohorts, edentulous adults (0 teeth) had a higher cumulative incidence of all-cause mortality than adults with 20-32 teeth (RR 2.27, 95% CI 1.82 to 2.83; 8 cohort studies, I2=94%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).

1 finding from 1 review

Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report
RR 2.27 [1.82, 2.83]
8 studies · 180222 participants
High