What do systematic reviews say?

Adults: higher dose/longer course vs lower dose/shorter course

It is very uncertain whether adults: higher dose/longer course changes all adverse events compared with lower dose/shorter course (very low certainty).

• Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
  OR 4.15 [0.94, 18.41]
  1 study · 43 participants
  Very low

Children: higher dose/longer course vs lower dose/shorter course

Children: higher dose/longer course showed no clear difference in all adverse events compared with lower dose/shorter course (moderate certainty).

• Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
  OR 0.67 [0.11, 4.08]
  1 study · 201 participants
  Moderate

Decision aids for informed consent vs usual care

• Decision aids for people facing health treatment or screening decisions 2024 · Cochrane Headline outcomes only
  no estimate extracted
  22 studies · 3707 participants
  High

Comprehensive geriatric assessment (CGA) vs usual care

It is very uncertain whether comprehensive Geriatric Assessment changes serious adverse events (falls) Median compared with usual care (very low certainty).

• Comprehensive Geriatric Assessment for community‐dwelling, high‐risk, frail, older people 2022 · Cochrane Headline outcomes only
  RR 0.82 [0.58, 1.17]
  2 studies · 1380 participants
  Very low

Intervention not reported

The intervention showed no clear difference in incidence of adverse events ‐ overall (moderate certainty).

• Antibiotics for preventing lower respiratory tract infections in high‐risk children aged 12 years and under 2015 · Cochrane Headline outcomes only
  RR 1.1 [0.75, 1.64]
  3 studies · 1344 participants
  Moderate