Findings

What do systematic reviews say?

2 questions · 2 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 1 · 50%High 1 · 50%

Tiotropium vs ipratropium

All‐cause serious adverse events · chronic obstructive pulmonary disease (COPD). Participants in included studies had an average baseline FEV1 of around 40% predicted and…

Tiotropium leads to lower all‐cause serious adverse events compared with ipratropium (high certainty).

1 finding from 1 review

Tiotropium versus ipratropium bromide for chronic obstructive pulmonary disease 2015 · Cochrane Headline outcomes only
OR 0.5 [0.34, 0.73]
2 studies · 1073 participants
High

Efficacy and safety of a first dose of whole‐cell pertussis vaccine vs a first dose of acellular pertussis vaccine

All‐cause serious adverse events · the promotion of growth and prevention of infections in infants less than six months of age

Efficacy and safety of a first dose of whole‐cell pertussis vaccine showed no clear difference in all‐cause serious adverse events compared with a first dose of acellular pertussis vaccine (moderate certainty).

1 finding from 1 review

Whole‐cell pertussis vaccine in early infancy for the prevention of allergy in children 2021 · Cochrane Headline outcomes only
RR 0.94 [0.78, 1.15]
15 studies · 38072 participants
Moderate