Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 3 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Piperacillin vs ampicillin plus amikacin

All‐cause mortality maximum · neonates with early‐onset sepsis

It is very uncertain whether piperacillin changes all‐cause mortality maximum compared with ampicillin plus amikacin (very low certainty).

1 finding from 1 review

Antibiotic regimens for early‐onset neonatal sepsis 2021 · Cochrane Headline outcomes only
RR 0.62 [0.35, 1.1]
1 study · 396 participants
Very low

Piperacillin plus tazobactam vs amikacin

All‐cause mortality maximum · neonates with early‐onset sepsis

It is very uncertain whether piperacillin plus tazobactam changes all‐cause mortality maximum compared with amikacin (very low certainty).

1 finding from 1 review

Antibiotic regimens for early‐onset neonatal sepsis 2021 · Cochrane Headline outcomes only
RR 0.32 [0.01, 7.61]
1 study · 59 participants
Very low

Ticarcillin plus clavulanic acid vs piperacillin plus gentamicin

All‐cause mortality maximum · neonates with early‐onset sepsis

It is very uncertain whether ticarcillin plus clavulanic acid changes all‐cause mortality maximum compared with piperacillin plus gentamicin (very low certainty).

1 finding from 1 review

Antibiotic regimens for early‐onset neonatal sepsis 2021 · Cochrane Headline outcomes only
RR 0.75 [0.19, 2.9]
1 study · 72 participants
Very low