Findings

What do systematic reviews say?

2 questions · 2 findings · 2 reviews · Neonatal

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 50%Low 1 · 50%Moderate 0 · 0%High 0 · 0%

Tramadol vs no treatment or placebo

All‐cause mortality during hospital stay · postoperative pain in preterm and term infants

It is very uncertain whether tramadol changes all‐cause mortality during initial hospitalization compared with no treatment or placebo (very low certainty).

1 finding from 1 review

Systemic opioids versus other analgesics and sedatives for postoperative pain in neonates 2023 · Cochrane Headline outcomes only
RR 0.32 [0.01, 7.7]
1 study · 71 participants
Very low

Clonidine vs placebo

All‐cause mortality during hospital stay · neonates with mechanical ventilation

Clonidine showed no clear difference in all‐cause mortality during initial hospitalization compared with placebo (low certainty).

1 finding from 1 review

Clonidine for sedation and analgesia for neonates receiving mechanical ventilation 2017 · Cochrane Headline outcomes only
RR 0.69 [0.12, 3.98]
1 study · 112 participants
Low