Findings

What do systematic reviews say?

2 questions · 2 findings · 2 reviews · Emergency and Critical Care

Sort:Best matchNewest Highest certainty Download CSV

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 2 · 100%High 0 · 0%

Corticosteroids vs placebo or usual care

28‐Day all‐cause mortalitya · children and adults with sepsis

Corticosteroids probably leads to lower 28‐Day all‐cause mortalitya compared with placebo or usual care (moderate certainty).

1 finding from 1 review

Corticosteroids for treating sepsis in children and adults 2019 · Cochrane Headline outcomes only
RR 0.91 [0.84, 0.99]
50 studies · 11233 participants
Moderate

Human recombinant activated protein C vs placebo

28‐Day all‐cause mortality (adult and paediatric patients) · patients with severe sepsis or septic shock

Human recombinant activated protein C showed no clear difference in 28‐Day all‐cause mortality (adult and paediatric patients) compared with placebo (moderate certainty).

1 finding from 1 review

Human recombinant protein C for severe sepsis and septic shock in adult and paediatric patients 2012 · Cochrane Headline outcomes only
RR 1 [0.86, 1.16]
6 studies · 6781 participants
Moderate