Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Heart

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 3 · 42.9%Low 3 · 42.9%Moderate 1 · 14.3%High 0 · 0%

All‐cause mortality · participants with high risk of sudden cardiac death (secondary prevention)

Amiodarone showed no clear difference in all‐cause mortality compared with other antiarrhythmics (low certainty).

1 finding from 1 review

Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
RR 1.03 [0.75, 1.42]
5 studies · 898 participants
Low

All‐cause mortality · participants with high risk of sudden cardiac death (secondary prevention)

It is very uncertain whether amiodarone changes all‐cause mortality compared with beta blockers (very low certainty).

1 finding from 1 review

Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
RR 0.96 [0.7, 1.32]
1 study · 189 participants
Very low

All‐cause mortality · participants with high risk of sudden cardiac death (secondary prevention)

It is very uncertain whether amiodarone changes all‐cause mortality compared with sotalol (very low certainty).

1 finding from 1 review

Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
RR 1.08 [0.41, 2.83]
2 studies · 104 participants
Very low

All‐cause mortality · participants with high risk of sudden cardiac death (primary prevention)

Amiodarone showed no clear difference in all‐cause mortality compared with placebo or no treatment (low certainty).

1 finding from 1 review

Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
RR 0.88 [0.78, 1]
17 studies · 8383 participants
Low

All‐cause mortality · beta blockers

Amiodarone may leads to lower all‐cause mortality compared with beta blockers (low certainty).

1 finding from 1 review

Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
RR 0.27 [0.1, 0.75]
2 studies · 342 participants
Low

All‐cause mortality · participants with high risk of sudden cardiac death (primary prevention)

Amiodarone probably leads to lower all‐cause mortality compared with other antiarrhythmics (moderate certainty).

1 finding from 1 review

Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
RR 0.37 [0.18, 0.76]
3 studies · 540 participants
Moderate

All‐cause mortality · participants with high risk of sudden cardiac death (secondary prevention)

It is very uncertain whether amiodarone changes all‐cause mortality compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
RR 3.05 [1.33, 7.01]
2 studies · 440 participants
Very low