What do systematic reviews say?

Self‐management interventions vs usual care

Self‐management interventions showed no clear difference in all‐cause mortality compared with usual care (low certainty).

• Self‐management interventions for people with chronic obstructive pulmonary disease 2022 · Cochrane Headline outcomes only
  OR 0.86 [0.59, 1.26]
  5719 participants
  Low
• Self‐management interventions including action plans for exacerbations versus usual care in patients with chronic… 2017 · Cochrane Headline outcomes only
  OR 1.06 [0.71, 1.59]
  16 studies · 3296 participants
  Moderate

Hydroxyurea vs placebo

• Interventions for chronic kidney disease in people with sickle cell disease 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 193 participants
  Low