Findings

What do systematic reviews say?

3 questions · 3 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 100%Moderate 0 · 0%High 0 · 0%

Early vs late continuous positive airway pressure (CPAP)

Pulmonary air leak defined as pneumothorax · preterm infants with respiratory distress for initial respiratory support

Early showed no clear difference in air leak (pneumothorax) compared with late continuous positive airway pressure (CPAP) (low certainty).

1 finding from 1 review

Early versus delayed continuous positive airway pressure (CPAP) for respiratory distress in preterm infants 2020 · Cochrane Headline outcomes only
RR 1.09 [0.39, 3.04]
3 studies · 98 participants
Low

Prophylactic CPAP vs mechanical ventilation

Pulmonary air leak defined as pneumothorax · preterm infants

Prophylactic CPAP showed no clear difference in pulmonary air leak defined as pneumothorax compared with mechanical ventilation (low certainty).

1 finding from 1 review

Prophylactic or very early initiation of continuous positive airway pressure (CPAP) for preterm infants 2021 · Cochrane Headline outcomes only
RR 1.24 [0.91, 1.69]
3 studies · 2357 participants
Low

Prophylactic or very early CPAP vs supportive care

Pulmonary air leak defined as pneumothorax · preterm infants

Prophylactic or very early CPAP showed no clear difference in pulmonary air leak defined as pneumothorax compared with supportive care (low certainty).

1 finding from 1 review

Prophylactic or very early initiation of continuous positive airway pressure (CPAP) for preterm infants 2021 · Cochrane Headline outcomes only
RR 0.75 [0.35, 1.16]
3 studies · 568 participants
Low